Peroxisome Proliferator Activated Receptors: From Basic Science to Clinical Applications

1. PPARγ: From Basic Science to Clinical Applications

   1. Peroxisome Proliferator Activator Receptor Gamma Agonists Inhibit the Development of Atherosclerosis in Low Density Lipoprotein Receptor-Deficient Male Mice

      • Andrew C. Li, Christopher K. Glass

      Pages 143-148

   2. Are Thiazolidinediones Superior to Standard Therapy in the Treatment of Type 2 Diabetes?

      • Marja-Riitta Taskinen

      Pages 149-155

2. Clinical Studies with PPAR Ligands

   1. PParγ Ligands and Intestinal Inflammation

      • Anne Flanigan, Thomas A. Judge, James D. Lewis, Robert J. Stein, Gary R. Lichtenstein, Julius J. Deren et al.

      Pages 157-162

   2. Inflammatory Mechanisms in Alzheimer’s Disease: β-Amyloid-Stimulated Proinflammatory Responses are Blocked by PPARγ Agonists

      • Gary Landreth, Colin Combs, J. Colleen Karlo, Sophia Sundararajan

      Pages 163-168

3. Back Matter

   Pages 169-172

   PDF

Peroxisome Proliferator Activated Receptors (PPARs) attract great attention in light of the wide spectrum of genes of biological and medical relevance identified as under their control. As a consequence, our knowledge of the role of these receptors in physiology and pathology continues to grow at a fast pace and PPARs have become an interesting target for the treatment of many pathological conditions, including diabetes and atherosclerosis. This volume provides an authoritative view of the current clinical and scientific developments within this evolving area of study.

• Activation
• Lipid
• Macrophages
• Peroxisom
• inflammatory response
• influence
• metabolism
• molecular mechanisms
• pathophysiology
• physiology
• proteins
• regulation

• Faculté des Sciences Pharmaceutiques et Biologiques, Inserm U 545, Dept. Atherosclerose, Institut Pasteur de Lille, Université de Lille II, Lille, France

  J.-C. Fruchart

• Weill Medical College of Cornell University, New York, USA

  A. M. Gotto

• Department of Pharmacological Sciences, University of Milan, Milan, Italy

  R. Paoletti, A. L. Catapano

• Department of Atherosclerosis, Pasteur Institute, Inserm U 545, University of Lille II, Lille, France

  B. Staels

Policies and ethics