ATP and the Heart

  • Joanne S. Ingwall

Part of the Basic Science for the Cardiologist book series (BASC, volume 11)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. ATP: The Molecule

    1. Front Matter
      Pages 1-1
    2. Joanne S. Ingwall
      Pages 3-6
    3. Joanne S. Ingwall
      Pages 7-20
    4. Joanne S. Ingwall
      Pages 21-37
  3. ATP: Degradation Pathway and de novo Synthesis

    1. Front Matter
      Pages 53-53
    2. Joanne S. Ingwall
      Pages 55-99
  4. ATP Utilizing Pathways

    1. Front Matter
      Pages 101-101
    2. Joanne S. Ingwall
      Pages 103-124
    3. Joanne S. Ingwall
      Pages 125-137
  5. ATP Synthesizing Pathways

    1. Front Matter
      Pages 145-145
    2. Joanne S. Ingwall
      Pages 165-196
  6. ATP and the Heart

    1. Front Matter
      Pages 215-215
  7. Back Matter
    Pages 241-244

About this book

Introduction

ATP plays a central role in the two leading causes of cardiac morbidity and mortality in the western world: ischemia and heart failure. We are in our infancy applying what is known about biology and chemistry of ATP toward developing effective therapies for these diseases. In this volume, the current understanding of the chemistry and biology of ATP specifically in the cardiomyocyte is presented. New insights into ATP have been gleaned using biophysical techniques allowing dynamic measurement of chemical events in the intact beating heart and using new animal models in which cardiac proteins are either over expressed, deleted or harbor specific mutations.

This book provides a summary of the basic understanding and includes illustrations of why ATP and the Heart is important to both the clinician and scientist.

Keywords

basics biology chemistry diseases heart heart failure molecule morbidity mortality mutation protein proteins

Authors and affiliations

  • Joanne S. Ingwall
    • 1
    • 2
  1. 1.Division of Cardiovascular Medicine, Department of MedicineBrigham and Women’s HospitalBoston
  2. 2.Harvard Medical SchoolBoston

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-1093-2
  • Copyright Information Kluwer Academic Publishers 2002
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-5391-1
  • Online ISBN 978-1-4615-1093-2
  • Series Print ISSN 1566-0753
  • About this book