Non-Myeloablative Allogeneic Transplantation

  • Asad Bashey
  • Edward D. Ball

Part of the Cancer Treatment and Research book series (CTAR, volume 110)

Table of contents

  1. Front Matter
    Pages i-x
  2. Januario E. Castro, Edward D. Ball
    Pages 1-37
  3. Angelo M. Carella, Germana Beltrami, Enrica Lerma, Marina Cavaliere, Maria T. Corsetti
    Pages 101-112
  4. Jody Donahue, Ewa Carrier
    Pages 177-211
  5. Back Matter
    Pages 213-216

About this book

Introduction

Non-myeloablative allogeneic stem cell transplantation (also known as mini-transplantation or reduced-intensity conditioning transplantation) is a major advance in the field of hematopoietic transplantation within the last 5 years. This approach uses non-cytotoxic or reduced-intensity cytotoxic therapy to prepare patients for allografting of hematopoietic stem cells and lymphocytes. It has the potential to deliver the potent anti-tumor immunotherapy and bone marrow replacement capacity of allogeneic stem cell transplantation to patients with reduced treatment-related morbidity and mortality. It may also enable allogeneic transplantation in patients who would be considered ineligible for conventional transplants because of co-morbidity or advanced age. However, this approach may necessitate more careful monitoring of post-transplant chimerism and malignant disease-status than is usual with conventional allografting. There is also controversy regarding the best preparative regimen and graft-versus-host disease prophylaxis to use.

Keywords

Immunosuppression bone marrow cell hematopoietic stem cell hematopoietic stem cell transplantation immunotherapy lymphocytes morbidity mortality stem cell stem cell transplantation stem cells transplantation

Editors and affiliations

  • Asad Bashey
    • 1
  • Edward D. Ball
    • 1
  1. 1.Blood and Marrow Transplantation DivisionUniversity of CaliforniaSan DiegoUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-0919-6
  • Copyright Information Kluwer Academic Publishers 2002
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-5304-1
  • Online ISBN 978-1-4615-0919-6
  • Series Print ISSN 0927-3042
  • About this book