Molecular Mechanisms of Metal Toxicity and Carcinogenesis

  • Xianglin Shi
  • Vince Castranova
  • Val Vallyathan
  • William G. Perry

Part of the Developments in Molecular and Cellular Biochemistry book series (DMCB, volume 34)

Table of contents

  1. Front Matter
    Pages i-1
  2. Molecular mechanisms of metal toxicity and carcinogenesis

  3. Cadmium-induced apoptosis and phenotypic changes in mouse thymocytes

    1. Suyun Dong, Han-Ming Shen, Choon-Nam Ong
      Pages 11-20
  4. Cytotoxicity and transcriptional activation of stress genes in human liver carcinoma cells (HepG2)exposed to cadmium chloride

  5. Arsenic-induced NFKB transactivation through Erks-and JNKs-dependent pathways in mouse epidermal JB6 cells

    1. Chuanshu Huang, Jingxia Li, Min Ding, Liying Wang, Xianglin Shi, Vincent Castranova et al.
      Pages 29-34
  6. Lead-related effects on rat fibroblasts

    1. Iva Iavicoli, Alessandro Sgambato, Giovanni Carelli, Raffaele Ardito, Achille Cittadini, Nicolè Castellino
      Pages 35-40
  7. In vivoreduction of chromium (VI) and its related free radical generation

  8. Atrazine potentiation of arsenic trioxide-induced cytotoxicity and gene expression in human liver carcinoma cells (HepG2)

    1. Paul B. Tchounwou, Barbara A. Wilson, Ali B. Ishaque, John Schneider
      Pages 49-59
  9. CombiningDrosophila melanogastersomatic-mutation-recombination and electron-spin-resonance-spectroscopy data to interpret epidemiologic observations on chromium carcinogenicity

  10. Carcinogenic potential and genomic instability of beryllium sulphate in BALB/c-3T3 cells

    1. Nagalakshmi Keshava, Gu Zhou, Michelle Spruill, Mang Ensell, Tong-man Ong
      Pages 69-76
  11. Cr (VI) induces cell growth arrest through hydrogen peroxide-mediated reactions

    1. Zhuo Zhang, Stephen S. Leonard, Suwei Wang, Val Vallyathan, Vince Castranova, Xianglin Shi
      Pages 77-83
  12. Comparison of roles of three mitogen-activated protein kinases induced by chromium(VI) and cadmium in non-small-cell lung carcinoma cells

  13. Differential zinc and DNA binding by partial peptides of human protamine HP2

    1. Wojciech Bal, Marcin Dyba, Zbigniew Szewczuk, Małgorzata Jeżowska-Bojczuk, Jan Lukszo, Gayatri Ramakrishna et al.
      Pages 97-106
  14. Reduction of Cr (VI) by cysteine: Significance in human lymphocytes and formation of DNA damage in reactions with variable reduction rates

    1. George Quievryn, Margarida Goulart, Joseph Messer Zhitkovich, Anatoly Zhitkovich
      Pages 107-118
  15. Transactivation of RARE and GRE in the Cellular Response to Arsenic

    1. Chuanshu Huang, Jingxia Li, Min Ding, Max Costa, Vincent Castranova, Val Vallyathan et al.
      Pages 119-125
  16. Orthopaedic implant related metal toxicity in terms of human lymphocyte reactivity to metal-protein complexes produced from cobalt-base and titanium-base implant alloy degradation

  17. Arsenic contamination of groundwater and prevalence of arsenical dermatosis in the Hetao plain area, Inner Mongolia, China

    1. Xiao juan Guo, Yoshihisa Fujino, Satoshi Kaneko, Kegong Wu, Yajuan Xia, Takesumi Yoshimura
      Pages 137-140
  18. Involvement of Erks activation in cadmium-induced AP-1 transactivationin vitroandin vivo

    1. Chuanshu Huang, Qunwei Zhang, Jingxia Li, Xianglin Shi, Vincent Castranova, Gong Ju et al.
      Pages 141-147
  19. Chromium (vi)-induced oxidative stress, apoptotic Cell death and modulation of p53 tumor suppressor Gene

  20. Review

    1. Fei Chen, Min Ding, Vince Castranova, Xianglin Shi
      Pages 159-171
    2. Travis O’Brien, Jian Xu, Steven R. Patierno
      Pages 173-182
  21. Mini Review

    1. Fei Chen, Val Vallyathan, Vince Castranova, Xianglin Shi
      Pages 183-188
    2. Yong Qian, Bing-Hua Jiang, Daniel C. Flynn, Stephen S. Leonard, Suiwei Wang, Zhuo Zhang et al.
      Pages 199-204
    3. Max Costa, Jessica E. Sutherland, Wu Peng, Konstantin Salnikow, Limor Broday, Thomas Kluz
      Pages 205-211
    4. Dmitriy Krepkiy, William E. Antholine, Charles Myers, David H. Petering
      Pages 213-219
    5. Kejian Liu, John Husler, Jianping Ye, Stephen S. Leonard, Debbie Cutler, Fei Chen et al.
      Pages 221-229
  22. Back Matter
    Pages 231-242

About this book


During the last two decades, chemical and cellular studies have contributed enormously to our understanding of metal-induced carcinogenesis, and many hypotheses on the role of metals in pathophysiological processes have been investigated. In addition, new techniques are available to shed light on the mechanism of carcinogenesis in molecular terms. This conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis in September 2000 focused on the latest research in molecular mechanisms of metal-induced toxicity and carcinogenesis. The conference promoted a multidisciplinary investigative approach and included presentations from international experts on state-of-the-art information in this field.


DNA apoptosis carcinoma gene expression transcription

Editors and affiliations

  • Xianglin Shi
    • 1
  • Vince Castranova
    • 1
  • Val Vallyathan
    • 1
  • William G. Perry
    • 2
  1. 1.Pathology and Physiology Research BranchNational Institute for Occupational Safety and HealthMorgantownUSA
  2. 2.Occupational Safety and Health AdministrationWashington DCUSA

Bibliographic information