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Rational Design of Stable Protein Formulations

Theory and Practice

  • John F. Carpenter
  • Mark C. Manning

Part of the Pharmaceutical Biotechnology book series (PBIO, volume 13)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Byeong S. Chang, Susan Hershenson
    Pages 1-25
  3. Tsutomu Arakawa, Tiansheng Li, Linda O. Narhi
    Pages 27-60
  4. Brent S. Kendrick, Tiansheng Li, Byeong S. Chang
    Pages 61-84
  5. John F. Carpenter, Beyong S. Chang, William Garzon-Rodriguez, Theodore W. Randolph
    Pages 109-133
  6. Geoffrey Lee
    Pages 135-158
  7. Theodore W. Randolph, LaToya S. Jones
    Pages 159-175
  8. Back Matter
    Pages 199-206

About this book

Introduction

Recombinant proteins and polypeptides continue to be the most important class of biotechnology-derived agents in today's pharmaceutical industry. Over the past few years, our fundamental understanding of how proteins degrade and how stabilizing agents work has made it possible to approach formulation of protein pharmaceuticals from a much more rational point of view.

This book describes the current level of understanding of protein instability and the strategies for stabilizing proteins under a variety of stressful conditions.

Keywords

Glycin Oxidation Polypeptide biotechnology databases preparation primary structure protein proteins

Editors and affiliations

  • John F. Carpenter
    • 1
  • Mark C. Manning
    • 1
  1. 1.University of Colorado Health Sciences CenterDenverUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-0557-0
  • Copyright Information Kluwer Academic/Plenum Publishers, New York 2002
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-5131-3
  • Online ISBN 978-1-4615-0557-0
  • Series Print ISSN 1078-0467
  • Buy this book on publisher's site