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The Sodium-Hydrogen Exchanger

From Molecule to its Role in Disease

  • Morris Karmazyn
  • Metin Avkiran
  • Larry Fliegel

Table of contents

  1. Front Matter
    Pages i-xxxii
  2. Kenneth W. Spitzer, Richard D. Vaughan-Jones
    Pages 1-15
  3. John Orlowski, Sergio Grinstein
    Pages 17-34
  4. Shigeo Wakabayashi, Tianxiang Pang, Takashi Hisamitsu, Munekazu Shigekawa
    Pages 35-49
  5. Henry J. Binder, Vazhaikkurichi M. Rajendran, John Geibel
    Pages 71-90
  6. Etana Padan, Abraham Rimon, Tzvi Tzubery, Marcus Müller, Katia Herz, Livnat Galili
    Pages 91-108
  7. Larry Fliegel, Morris Karmazyn
    Pages 109-122
  8. Horacio E. Cingolani, Néstor G. Pérez, Irene L. Ennis, María C. Camilión de Hurtado
    Pages 137-148
  9. Peter J. Little, Rodney J. Dilley
    Pages 159-175
  10. John W. Phillis, Julie G. Pilitsis, Michael H. O’Regan
    Pages 177-189
  11. Robert S. Haworth, Metin Avkiran
    Pages 191-209
  12. Hans Jochen Lang
    Pages 239-253
  13. Wolfgang Scholz, Norbert Beier
    Pages 255-264
  14. Garrett J. Gross
    Pages 265-278
  15. Back Matter
    Pages 309-317

About this book

Introduction

I am extremely honored and pleased to have the opportunity to write a few introductory words for this timely volume on Na + /It exchange. This is a field of investigation that I entered into by challenge and necessity, embraced with passion and fmally left in my quest for new discoveries in growth control. Ten years, one third of my scientific life, has been devoted to uncovering the mysteries of intracellular pH (PH;) regulation with respect to growth factor action. I got started on this new topic in 1980, when I heard a rather provocative hypothesis presented by Enrique Rozengurt at an ICN-UCLA Keystone meeting on "Cell Surface and Malignancy". He showed that all mitogens induced amiloride-sensitive Na + entry into resting cells and proposed that, if a compound stimulates Na + influx, it could be a mitogen. In support of his proposal Enrique reported that the amphipathic polypeptide, mellitin, which induced Na+ influx, was indeed mitogenic for 3T3 cells. This was only correlation at this stage. However, I was fascinated by this talk. I immediately approached Enrique to inform him of my skepticism about this beautiful story, and to indicate that I would only be convinced when I succeeded in isolating mutant fibroblasts lacking the amiloride-sensitive Na+ transporter. ''Good luck!" was his response.

Keywords

Activation Colon Escherichia coli genes regulation transcription

Editors and affiliations

  • Morris Karmazyn
    • 1
  • Metin Avkiran
    • 2
  • Larry Fliegel
    • 3
  1. 1.University of Western OntarioLondonCanada
  2. 2.King’s College LondonUK
  3. 3.University of AlbertaEdmontonCanada

Bibliographic information