Signal Transduction and Cardiac Hypertrophy

  • Naranjan S. Dhalla
  • Larry V. Hryshko
  • Elissavet Kardami
  • Pawan K. Singal

Part of the Progress in Experimental Cardiology book series (PREC, volume 7)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Cardiac Adaptation and Remodeling

    1. Front Matter
      Pages 1-1
    2. Florian Grabellus, Bodo Levkau, Hans-H. Scheld, Atsushi Takeda, Michael Erren, Jörg Stypmann et al.
      Pages 3-18
    3. Horacio E. Cingolani, Néstor G. Perez, María C. Camilión de Hurtado
      Pages 37-48
    4. Emanuele Giordano, Lisa M. Shantz, Rebecca A. Hillary, Carlo Guarnieri, Claudio M. Caldarera, Anthony E. Pegg
      Pages 49-56
    5. Hideaki Kawaguchi, Noriteru Morita, Takeshi Murakami, Kenji Iizuka
      Pages 57-67
    6. František Kolář, Ivana Ošt’ádalová, Bohuslav Ošt’ádal, Jan Neckář, Ondrej Szárszoi
      Pages 69-83
    7. Hiroyuki Takano, Yunzeng Zou, Hiroshi Akazawa, Toshio Nagai, Miho Mizukami, Haruhiro Toko et al.
      Pages 85-94
    8. Barbara Knoblach, Kimitoshi Nakamura, Murray Robertson, Marek Michalak
      Pages 95-103
    9. María C. Camilión de Hurtado, Néstor G. Pérez, Irene L. Ennis, Bernardo V. Alvarez, Horacio E. Cingolani
      Pages 125-135
  3. Cardiac Signal Transduction

    1. Front Matter
      Pages 137-137
    2. Ernesto Alejandro Aiello
      Pages 139-147
    3. Ranjinder S. Sidhu, Richard R. Clough, Rajinder P. Bhullar
      Pages 167-179
    4. Robert Denyer, Sandhya Sanghi, Rajesh Kumar, David E. Dostal
      Pages 181-198
    5. Claudio Stefanelli, Carla Pignatti, Benedetta Tantini, Emanuele D. Giordano Francesca Bonavita, Maddalena Zini, Flavio Flamigni et al.
      Pages 199-206

About this book


Cellular signaling in cardiac muscle refers to the myriad of stimuli and responses that direct and control the physiological operation of this organ. Our understand­ ing of these complex signaling cascades has increased dramatically over the past few decades with the advent of molecular tools for their dissection. Moreover, this infor­ mation is beginning to provide tangible targets towards manipulating cardiac func­ tion in the setting of cardiovascular disease. The mechanisms and factors that regulate cardiac cell growth are of particular interest as both adaptive and maladaptive responses can occur during cardiac hypertrophy. Cardiac hypertrophy describes the increase in individual cardiac myocyte size that is accomplished through the series and/or parallel addition of sarcomeres. The ability of cardiac muscle to increase in size through hyperplasia becomes highly restricted or negligible shortly after birth. Consequently, the increase in heart size associated with development and growth of an individual occurs through hypertrophy. In response to a chronic increase in workload, cardiac muscle cells can dramatically increase in size to face their increasing contractile demands. While this plasticity is clearly a ben­ eficial response under many conditions, it can be highly deleterious and inappropri­ ate under others. For example, cardiac hypertrophy associated with endurance exercise clearly enhances athletic performance. In contrast, the hypertrophy associated with chronic hypertension, stenotic or regurgitant heart valves, or following a myocardial infarction often continues far beyond the period where this adaptive response is ben­ eficial.


heart heart failure myocardial infarction

Editors and affiliations

  • Naranjan S. Dhalla
    • 1
  • Larry V. Hryshko
    • 1
  • Elissavet Kardami
    • 1
  • Pawan K. Singal
    • 1
  1. 1.Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre Faculty of MedicineUniversity of ManitobaWinnipegCanada

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 2003
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-5032-3
  • Online ISBN 978-1-4615-0347-7
  • Series Print ISSN 1389-1774
  • About this book