DNA Topoisomerases in Cancer Therapy

Present and Future

  • Toshiwo Andoh

Table of contents

  1. Front Matter
    Pages i-xii
  2. James C. Wang
    Pages 1-13
  3. Yves Pommier, Juana Barceló, Takahisa Furuta, Haruyuki Takemura, Olivier Sordet
    Pages 15-52
  4. Kenneth D. Bromberg, Neil Osheroff
    Pages 53-78
  5. Hervé R. Jacquiau, Mary-Ann Bjornsti
    Pages 89-107
  6. Kae Yanase, Toshiwo Andoh
    Pages 129-143
  7. Yves Pommier, ZhiYong Liao, LingHua Meng
    Pages 145-165
  8. Toshiwo Andoh, Ken Umemura, Kae Yanase, Takao Yamori
    Pages 167-188
  9. Back Matter
    Pages 189-202

About this book


In the mid 80's type I and II enzymes were found to be the intracellular targets of a number of efficacious anticancer drugs such as doxorubicin, mitoxantrone, etoposide and camptothecin as a result of a continued efforts of many investigators, especially Leroy Liu and his collaborators at Johns Hopkins University. Readers will find a series of chapters written by researchers actively engaged in the expanding field of topoisomerase and their inhibitors. The series of chapters cover review articles on pharmacology and the molecular mechanism of topoisomerase I- and II-targeting anticancer drugs in mammals and in the yeast Saccharomyces cerevisiae, which has proved to be a superb model organism for studies of anticancer drugs. This volume compiles up-to-date information on the topoisomerase-targeting compounds in clinical and preclinical development as a useful and important reference book for students and researchers in the field of pharmacology, toxicology, oncology and molecular biology.


DNA biology cancer cell cell death enzyme enzymes molecular biology pharmacology protein resistance toxicology

Editors and affiliations

  • Toshiwo Andoh
    • 1
  1. 1.Department of Bioengineering Faculty of EngineeringSoka UniversityHachiojiTokyoJapan

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic/Plenum Publishers, New York 2003
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-4941-9
  • Online ISBN 978-1-4615-0141-1
  • Buy this book on publisher's site