Molecular Aspects of Botulinum Neurotoxin

  • Keith A. Foster
Book

Part of the Current Topics in Neurotoxicity book series (Current Topics Neurotoxicity, volume 4)

Table of contents

  1. Front Matter
    Pages i-xii
    PDF
  2. Overview and History of Botulinum Neurotoxin Research
    Keith A. Foster
    Pages 1-7
  3. Pharmacology of Botulinum Neurotoxins: Exploitation of Their Multifunctional Activities as Transmitter Release Inhibitors and Neuron-Targeted Delivery Vehicles
    J. O. Dolly, V. B. O’Leary, G. W. Lawrence, S. V. Ovsepian
    Pages 9-33
  4. Absorption and Transport of Botulinum Neurotoxins
    Michel R. Popoff, Chloé Connan
    Pages 35-68
  5. The Botulinum Neurotoxin Complex and the Role of Ancillary Proteins
    Bal Ram Singh, Tzuu-Wang Chang, Roshan Kukreja, Shuowei Cai
    Pages 69-101
  6. Neurotoxin Structure
    Subramanyam Swaminathan
    Pages 103-127
  7. The Dual-Receptor Recognition of Botulinum Neurotoxins
    Andreas Rummel
    Pages 129-150
  8. Translocation, Entry into the Cell
    Matthew Beard
    Pages 151-170
  9. Protease Activity of the Botulinum Neurotoxins
    Sheng Chen, Joseph T. Barbieri
    Pages 171-189
  10. Molecular Basis for Persistence of Botulinum Neurotoxin: The Role of Intracellular Protein Degradation Pathways
    Yien Che Tsai, Brian E. Moller, Michael Adler, George A. Oyler
    Pages 191-205
  11. Clostridium botulinum Genomes and Genetic Diversity
    Theresa J. Smith
    Pages 207-228
  12. Botulinum Neurotoxin Risks and Detection in Environment, Agriculture and Food Chains
    Miia Lindström, Riikka Keto-Timonen, Hannu Korkeala
    Pages 229-258
  13. Botulism as a Disease of Humans
    Susan E. Maslanka
    Pages 259-289
  14. Prevention and Treatment of Botulism
    Michael Adler, Nizamettin Gul, Edward Eitzen, George Oyler, Brian Molles
    Pages 291-342
  15. Back Matter
    Pages 343-345
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About this book

Introduction

Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins, and is both up to date and authoritative.

Keywords

botox botulinum neurotoxin botulism dysport neurotoxin complex neurotoxin-associated proteins oculinum recombinant protein therapeutic agent

Editors and affiliations

  • Keith A. Foster
    • 1
  1. 1.Units 4-10Syntaxin Ltd.AbingdonUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-9454-6
  • Copyright Information Springer New York 2014
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-9453-9
  • Online ISBN 978-1-4614-9454-6
  • About this book