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  • © 2014

Advances in Tumor Immunology and Immunotherapy

  • Most up-to-date volume that explores evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and emerging strategies for manipulation of the immune system for therapeutic benefit that have realized success in neuroblastoma, leukemia, melanoma, lung cancer, and allogeneic transplantation

  • Highlights early successes as well as failures to provide a snapshot of the state of clinical immunotherapy with an eye to future possibilities such as combination therapies, adoptive T-cell transfer, and the retargeting of immune cells via T-cell receptor engineering

  • Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumor immunity and tumor evasion

Part of the book series: Current Cancer Research (CUCR)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-ix
  2. Immune Activation, Suppression and Manipulation of the Immune Antitumor Response

    1. Front Matter

      Pages 1-1
    2. Myeloid-Derived Suppressor Cells in Cancer

      • Christos E. Kyriakopoulos, Alberto J. Montero, Claudia Marcela Diaz-Montero
      Pages 3-17
    3. The Role of B Cells in Shaping the Antitumor Immune Response

      • Yu Zhang, Taylor H. Schreiber, Joseph D. Rosenblatt
      Pages 19-35
    4. Heat-Shock Protein-Based Cancer Immunotherapy

      • Taylor H. Schreiber
      Pages 37-56
    5. Employing T Cell Homeostasis as an Antitumor Strategy

      • Shawn M. Jensen, Christopher C. Paustain, Bernard A. Fox
      Pages 83-105
  3. Evolving Clinical Immunotherapeutic Strategies

    1. Front Matter

      Pages 123-123
    2. Immunotherapy in Renal Cell Carcinoma

      • Jennifer Cudris, Jaime R. Merchan
      Pages 125-147
    3. Bifunctional Antibodies: Preclinical and Clinical Applications

      • Casey W. Shuptrine, Louis M. Weiner
      Pages 183-211
    4. Clinical Development of Antibody-Fusion Proteins for Cancer Therapy

      • Kory L. Alderson, Amy K. Erbe, Margaret Boyden, Paul M. Sondel
      Pages 213-235
    5. T Cell Co-regulatory Signals and Their Role in Cancer Therapy

      • Eitan R. Friedman, Lynn Feun, Pasquale Benedetto, Joseph D. Rosenblatt
      Pages 323-341
  4. Back Matter

    Pages 365-371

About this book

Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets.

Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumor immunity and tumor evasion.

In addition to emerging understanding of tumor evasion, new immune targets such as CTLA4 blockade, NK stimulatory receptors, manipulation of the antigen processing and presentation, cytokine and costimulatory responses all provide new possibilities for enhancing anti-tumor immunity even in tumors previously felt to be resistant to immune attack. Several of these strategies have already been realized in the clinic. The volume will explore evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and emerging strategies for manipulation of the immune system for therapeutic benefit that have realized success in neuroblastoma, leukemia, melanoma, lung cancer, and allogeneic transplantation. Early successes as well as failures will be highlighted to provide a snapshot of the state of clinical immunotherapy with an eye to future possibilities such as combination therapies, adoptive T-cell transfer, and the retargeting of immune cells via T-cell receptor engineering.

Editors and Affiliations

  • Sylvester Comprehensive Cancer Center (SCCC), University of Miami School of Medicine, Miami, USA

    Joseph D. Rosenblatt

  • University of Miami Dept. Microbiology & Immunology, Miami, USA

    Eckhard R. Podack

  • University of Miami Sylvester Comprehensive Cancer Center, Miami, USA

    Glen N. Barber

  • Dept. Pediatrics, Louisiana State University Health Sciences Center, New Orleans, USA

    Augusto Ochoa

Bibliographic Information

  • Book Title: Advances in Tumor Immunology and Immunotherapy

  • Editors: Joseph D. Rosenblatt, Eckhard R. Podack, Glen N. Barber, Augusto Ochoa

  • Series Title: Current Cancer Research

  • DOI: https://doi.org/10.1007/978-1-4614-8809-5

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media New York 2014

  • Hardcover ISBN: 978-1-4614-8808-8Published: 25 October 2013

  • Softcover ISBN: 978-1-4939-5097-3Published: 23 August 2016

  • eBook ISBN: 978-1-4614-8809-5Published: 25 October 2013

  • Series ISSN: 2199-2584

  • Series E-ISSN: 2199-2592

  • Edition Number: 1

  • Number of Pages: IX, 371

  • Number of Illustrations: 6 b/w illustrations, 29 illustrations in colour

  • Topics: Cancer Research, Pharmacology/Toxicology

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access