Advances in Tumor Immunology and Immunotherapy

  • Joseph D. Rosenblatt
  • Eckhard R. Podack
  • Glen N. Barber
  • Augusto Ochoa

Part of the Current Cancer Research book series (CUCR)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Immune Activation, Suppression and Manipulation of the Immune Antitumor Response

    1. Front Matter
      Pages 1-1
    2. Christos E. Kyriakopoulos, Alberto J. Montero, Claudia Marcela Diaz-Montero
      Pages 3-17
    3. Yu Zhang, Taylor H. Schreiber, Joseph D. Rosenblatt
      Pages 19-35
    4. Taylor H. Schreiber
      Pages 37-56
    5. Shawn M. Jensen, Christopher C. Paustain, Bernard A. Fox
      Pages 83-105
  3. Evolving Clinical Immunotherapeutic Strategies

    1. Front Matter
      Pages 123-123
    2. Jennifer Cudris, Jaime R. Merchan
      Pages 125-147
    3. Casey W. Shuptrine, Louis M. Weiner
      Pages 183-211
    4. Kory L. Alderson, Amy K. Erbe, Margaret Boyden, Paul M. Sondel
      Pages 213-235
    5. Eitan R. Friedman, Lynn Feun, Pasquale Benedetto, Joseph D. Rosenblatt
      Pages 323-341
  4. Back Matter
    Pages 365-371

About this book

Introduction

This volume explores recent advances in understanding of fundamental immunology  and insights into  the dynamic interactions between tumors and the immune system, that  provide new opportunities  for therapeutic  intervention in cancer.  Chapter topics include evolving paradigms in the innate and adaptive response,   newly appreciated immunosuppressive mechanisms,  and  novel preclinical  strategies for manipulation of the immune system for therapeutic benefit in cancer. In addition, recent successes in the clinic, and emerging opportunities are covered. Future possibilities, such as the use of antibody engineering, fusion proteins,  and the retargeting of immune cells through T-cell receptor engineering are discussed by  leaders in the field,  focusing  on recent clinical experience, promising technologies, and challenges to clinical success.

Keywords

Antibody Cancer Immunology Immunotherapy T-cell Tumor

Editors and affiliations

  • Joseph D. Rosenblatt
    • 1
  • Eckhard R. Podack
    • 2
  • Glen N. Barber
    • 3
  • Augusto Ochoa
    • 4
  1. 1.Sylvester Comprehensive Cancer Center (SCCC)University of Miami School of MedicineMiamiUSA
  2. 2.University of Miami Dept. Microbiology & ImmunologyMiamiUSA
  3. 3.University of Miami Sylvester Comprehensive Cancer CenterMiamiUSA
  4. 4.Dept. PediatricsLouisiana State University Health Sciences CenterNew OrleansUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-8809-5
  • Copyright Information Springer Science+Business Media New York 2014
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine
  • Print ISBN 978-1-4614-8808-8
  • Online ISBN 978-1-4614-8809-5
  • About this book