Nuclear Signaling Pathways and Targeting Transcription in Cancer

  • Rakesh Kumar

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Gene Regulation and Cancer

    1. Front Matter
      Pages 1-1
    2. Shakur Mohibi, Shashank Srivastava, Hamid Band, Vimla Band
      Pages 33-55
    3. Jessica L. Brusgard, Antonino Passaniti
      Pages 57-86
    4. Jing Liang, Yongfeng Shang
      Pages 87-104
  3. Signaling Pathway and Cancer

    1. Front Matter
      Pages 105-105
    2. Elspeth M. Beauchamp, Ruth Serrano, Leonidas C. Platanias
      Pages 107-119
    3. Kunzang Chosdol, Mohita Bhagat, Bhawana Dikshit, Evanka Madan, Parthaprasad Chattopadhyay, Subrata Sinha
      Pages 121-154
    4. David M. Woods, Maritza Lienlaf-Moreno, Eduardo Sotomayor, Edward Seto, Alejandro Villagra
      Pages 155-187
    5. Chenguang Wang, Jun-Yuan Ji, Lifeng Tian, Richard G. Pestell
      Pages 259-275
  4. Protein Domains and Cancer Therapeutics

    1. Front Matter
      Pages 277-277
    2. Susanne Müller, Hannah Lingard, Stefan Knapp
      Pages 279-298
    3. Pratik Chandrani, Amit Dutt
      Pages 299-310
  5. Targeted Cancer Therapy

    1. Front Matter
      Pages 311-311
    2. Ana Rita Grosso, Maria Carmo-Fonseca
      Pages 313-336
    3. Ling-Yu Wang, Wenchang Guo, Kevin Kim, Mamata Pochampalli, Chiu-Lien Hung, Yoshihiro Izumiya et al.
      Pages 373-397
  6. Back Matter
    Pages 423-439

About this book


This book presents the most up-to-date information in the area of targeted therapeutics with a particular focus on pathway-centered approaches and transcription by leading authorities in molecular cancer research. The goal is to cover several critical principles of cancer therapeutics, ranging from regulation of cancer associated genes by coregulators, cancer cell signaling, modifiers of epigenome functionality and specific protein domains, and emerging significance of splicing. The book is directed for basic and translational scientists, clinicians, clinical investigators, fellows, residents, graduate students, and educators in the areas of molecular therapeutics and cancer medicine, and medical sciences at-large. Readers will be able to grasp the overall importance of the pathway, associated pathobiology and clinical manifestation, and possible points of intervention with a goal to solidify new cancer therapeutic targets.


Cancer Cancer Research Factors Modifiers Transcriptional

Editors and affiliations

  • Rakesh Kumar
    • 1
  1. 1.WashingtonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2014
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-8038-9
  • Online ISBN 978-1-4614-8039-6
  • Series Print ISSN 2196-9906
  • Series Online ISSN 2196-9914
  • Buy this book on publisher's site