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  • © 2013

Human Interphase Chromosomes

Biomedical Aspects

  • This is the first title to review modern achievements in the field of the post-genomic era’s genomics of interphase nuclei

  • Human Interphase Chromosomes play a significant role in a variety of basic biological processes involved in realization and inheritance of genetic information within and between species?

  • Provides special attention to available molecular cytogenetic technologies for basic and clinical chromosome research

  • Includes supplementary material: sn.pub/extras

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eBook USD 169.00
Price excludes VAT (USA)
  • ISBN: 978-1-4614-6558-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
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  • Tax calculation will be finalised during checkout
Hardcover Book USD 219.99
Price excludes VAT (USA)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xvii
  2. Introduction to Interphase Molecular Cytogenetics

    • Yuri B. Yurov, Svetlana G. Vorsanova, Ivan Y. Iourov
    Pages 1-8
  3. Interphase Chromosome Behavior in Normal and Diseased Cells

    • Gemma Bourne, Catherine Moir, Ural Bikkul, Mai Hassan Ahmed, Ian R. Kill, Christopher H. Eskiw et al.
    Pages 9-33
  4. Nuclear Architecture, Chromosome Aberrations, and Genetic Damage

    • Gustavo A. Folle, María Vittoria Di Tomaso, Laura Lafon-Hughes, Pablo Liddle
    Pages 35-51
  5. Interphase Chromosomes of the Human Brain: The Biological and Clinical Meaning of Neural Aneuploidy

    • Ivan Y. Iourov, Svetlana G. Vorsanova, Yuri B. Yurov
    Pages 53-83
  6. Interphase Cytogenetics at the Earliest Stages of Human Development

    • Darren K. Griffin, Gothami Fonseka, Helen G. Tempest, Alan R. Thornhill, Dimitris Ioannou
    Pages 123-138
  7. Organization of Chromosomes in Human Sperm Nucleus

    • Olga S. Mudrak, Liudmila V. Solovjeva, Vadim O. Chagin
    Pages 139-159
  8. Interphase Chromosome-Specific Multicolor Banding

    • Ivan Y. Iourov, Thomas Liehr, Svetlana G. Vorsanova, Yuri B. Yurov
    Pages 161-169
  9. Chromosome Architecture Studied by High-Resolution FISH Banding in Three Dimensionally Preserved Human Interphase Nuclei

    • Thomas Liehr, Hasmik Mkrtchyan, Marina Manvelyan, Tatyana Karamysheva, Elisabeth Klein, Samarth Bhatt
    Pages 171-178
  10. Technological Solutions in Human Interphase Cytogenetics

    • Svetlana G. Vorsanova, Yuri B. Yurov, Ivan Y. Iourov
    Pages 179-203
  11. Back Matter

    Pages 205-216

About this book

The beginning of interphase cytogenetics can be attributed to significant advances in human molecular genetics and cytogenetics. Owing to experimental and theoretical research at the interface between cellular and molecular levels of chromosomal organization and function, high-resolution techniques for chromosomal analysis (molecular cytogenetic techniques) have become available. Molecular cytogenetics is a branch of biomedical sciences that explores chromosomes at molecular and single-cell resolutions at all stages of the cell cycle. It also comprises the techniques that operate with either the entire genome or specific DNA sequences to analyze genomic structural and functional variations at chromosomal level. In postgenomic era, molecular cytogenetics has appreciably transformed and has given rise to a new field of genomics, called cytogenomics. As a result, new opportunities have emerged for analysis of human interphase chromosomes in almost all cell types and states at unprecedented resolution. In Human Interphase Chromosomes, the editors have provided an overview of current developments in the study of human interphase chromosomes with a special attention to available molecular cytogenetictechnologies for basic and clinical chromosome research.

Keywords

  • chromosome
  • cytogenetics
  • developmental biology
  • genetics

Editors and Affiliations

  • Mental Health Research Center, Laboratory of Cytogenetics, Russian Academy of Medical Sciences, Moscow, Russia

    Yuri B. Yurov

  • Institute of Pediatry & Children Surgery, Laboratory of Molecular Cytogenetics of, Ministry of Health, Moscow, Russia

    Svetlana G. Vorsanova

  • Mental Health Research Center, Laboratory of Molecular Brain Genetics, Russian Academy of Medical Sciences, Moscow, Russia

    Ivan Y. Iourov

About the editors

^400 publications.

 

Svetlana G. Vorsanova (PhD, Dr. Sci, professor) is a head of laboratory of molecular cy^600 publications.

 

Yuri B. Yurov (PhD, Dr. Sci, professor; 1951-2017) was a pioneer of interphase molecular cytogenetics. He was the founding editor of Molecular Cytogenetics (BMC/Springer/Nature). He has (co-)authored >650 publications, including descriptions of groundbreaking studies in molecular cytogenetics of the human brain.

Bibliographic Information

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • ISBN: 978-1-4614-6558-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Hardcover Book USD 219.99
Price excludes VAT (USA)