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Vesicle Trafficking in Cancer

  • Yosef Yarden
  • Gabi Tarcic

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Alexander Sorkin, Manojkumar A. Puthenveedu
    Pages 1-31
  3. Eli Zamir, Nachiket Vartak, Philippe I. H. Bastiaens
    Pages 57-74
  4. Giorgio Scita, Andrea Disanza, Emanuela Frittoli, Andrea Palamidessi, Sara Sigismund
    Pages 75-94
  5. Iwona Pilecka, Marta Miaczynska
    Pages 139-157
  6. Ying-Nai Wang, Jennifer L. Hsu, Mien-Chie Hung
    Pages 159-176
  7. Daniela Hoeller, Ivan Dikic
    Pages 177-190
  8. Elena Maspero, Hans-Peter Wollscheid, Simona Polo
    Pages 191-218
  9. Ke Ma, Stephen C. Kales, Marion M. Nau, Stanley Lipkowitz
    Pages 219-244
  10. Han Liu, Sylvie Urbé, Michael J. Clague
    Pages 245-259
  11. Carine Joffre, Rachel Barrow, Ludovic Ménard, Stéphanie Kermorgant
    Pages 261-277
  12. Elena Rainero, Peter V. E. van den Berghe, Jim C. Norman
    Pages 327-359
  13. Back Matter
    Pages 385-393

About this book

Introduction

Endocytosis and vesicular trafficking determine the landscape of the cell’s exterior, namely the density of surface molecules, such as receptors for growth factors and cytokines, adhesion molecules like integrins and cadherins, and a plethora of nutrient carriers. Hence, endocytosis is involved in signal transduction, cell adhesion and migration, as well as metabolism. To exploit these fundamental processes, malignancies subtly and multiply manipulate the endocytosis and the subsequent trafficking of protein cargoes. This is achieved by simultaneously altering the cytoskeleton, vesicle budding, cargo sorting and intracellular degradation. By highlighting the underlying molecular processes and concentrating on specific examples, this book reviews the recent emergence of derailed endocytosis and vesicular trafficking as a landmark of cancer. In-depth understanding of this common feature of tumors might lead the way to drug-induced strategies, able to rectify intracellular trafficking in cancer.

Keywords

C-Met signaling endocytosis endosomal pathway oxidative stress

Editors and affiliations

  • Yosef Yarden
    • 1
  • Gabi Tarcic
    • 2
  1. 1.Department of Biological RegulationRehovotIsrael
  2. 2., Department of Biological RegulationWeizmann Institute of ScienceRehovotIsrael

Bibliographic information