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Pharmacoresistance in Epilepsy

From Genes and Molecules to Promising Therapies

  • Contains the most up-to-date information on the development of pharmacoresistance in epileptic disorders

  • Discusses novel therapeutic strategies to counteract the development of pharmacoresistance

  • Of interest to both basic scientists and clinicians?

  • Includes supplementary material: sn.pub/extras

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xii
  2. Pharmacoresistance and Epilepsy

    • Francisco Rubio-Donnadieu
    Pages 1-9
  3. Genes Involved in Pharmacoresistant Epilepsy

    • Iris E. Martínez-Juárez, Laura Elena Hernández-Vanegas, Nayelli Rodríguez y Rodríguez, Jorge Alfredo León-Aldana, Antonio V. Delgado-Escueta
    Pages 11-25
  4. Molecular Mechanisms of Pharmacoresistant Epilepsy

    • Alberto Lazarowski, Liliana Czornyj
    Pages 47-57
  5. Modifications in the Seizures Susceptibility by Excitotoxic Neuronal Damage and Its Possible Relationship with the Pharmacoresistance

    • Monica E. Ureña-Guerrero, Alfredo I. Feria-Velasco, Graciela Gudiño-Cabrera, Antoni Camins Espuny, Carlos Beas-Zárate
    Pages 59-76
  6. Intracellular Pathways Associated with Neuronal Survival and Death in Epilepsy

    • Martha Rivera-Cervantes, Alfredo I. Feria-Velasco, Felix Junyent, Antoni Camins Espuny, Carlos Beas-Zárate
    Pages 77-97
  7. The Role of JNK Pathway in the Process of Excitotoxicity Induced by Epilepsy and Neurodegeneration

    • Carme Auladell, Felix Junyent, Aurelio Vazquez de la Torre, Maria Luisa de Lemos, Mercè Pallàs, Ester Verdaguer Cardona et al.
    Pages 99-113
  8. Proteomics-Based Strategy to Identify Biomarkers and Pharmacological Targets in Temporal Lobe Epilepsy

    • Maria José da Silva Fernandes, Rebeca Padrão Amorim, Jose Eduardo Marques Carneiro, Michelle Gasparetti Leão Araújo, Daniele Suzete Persike
    Pages 115-126
  9. Abnormalities of GABA System and Human Pharmacoresistant Epilepsy

    • Sandra Orozco-Suárez, David Escalante-Santiago, Iris Angélica Feria-Romero, Monica E. Ureña-Guerrero, Luisa Rocha, Mario A. Alonso-Vanegas et al.
    Pages 127-147
  10. Pharmacoresistant Epilepsy and Immune System

    • Lourdes Lorigados Pedre, Lilia Maria Morales Chacón, Sandra Orozco-Suárez, Luisa Rocha
    Pages 149-168
  11. Contribution of the Antiepileptic Drug Administration Regime in the Development and/or Establishment of Pharmacoresistant Epilepsy

    • Pietro Fagiolino, Marta Vázquez, Sandra Orozco-Suárez, Cecilia Maldonado, Silvana Alvariza, Iris Angélica Feria-Romero et al.
    Pages 169-184
  12. Experimental Models to Study Pharmacoresistance in Epilepsy

    • Cecilia Zavala-Tecuapetla, Luisa Rocha
    Pages 185-197
  13. Resistance to Epileptogenesis in the Neotropical Rodent Proechimys

    • Carla A. Scorza, Esper A. Cavalheiro
    Pages 199-205
  14. Vagus Nerve Stimulation for Intractable Seizures

    • Mario A. Alonso-Vanegas
    Pages 233-252
  15. The Role of Neuromodulation in the Treatment of Refractory Epilepsy

    • Ana Luisa Velasco, Francisco Velasco
    Pages 253-263
  16. Transcranial Magnetic Stimulation and Refractory Partial Epilepsy

    • Lilia Maria Morales Chacón, Lázaro Gómez Fernández, Otto Trápaga Quincoses, Genco Marcio Estrada Vinajera, Lourdes Lorigados Pedre, Marilyn Zaldivar Bermudes et al.
    Pages 265-289

About this book

Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease.

Clinicians and basic scientists alike will find up-to-date information on the development of pharmacoesistance, as well as reviews of mechanisms associated with epilepsy that may help them consider novel strategies for preventing the development of pharmacoresistance in the first place. The book also features information on new therapeutic strategies for control of epilepsy, such as transcutaneous electrical stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy: From Genes and Molecules to Promising Therapies is useful to anyone working in the field, whether they’re studying epilepsy in the lab or treating it in a doctor’s office.”

Keywords

  • epilepsy
  • neurotoxicity
  • pharmacoresistance
  • therapeutic strategies in epilepsy

Editors and Affiliations

  • , Pharmacobiology Department, Center for Research and Advanced Studies, Mexico City, Mexico

    Luisa Rocha

  • , Disciplina de Neurologia Experimental, UNIFESP/EPM, São Paulo, Brazil

    Esper A. Cavalheiro

Bibliographic Information

  • Book Title: Pharmacoresistance in Epilepsy

  • Book Subtitle: From Genes and Molecules to Promising Therapies

  • Editors: Luisa Rocha, Esper A. Cavalheiro

  • DOI: https://doi.org/10.1007/978-1-4614-6464-8

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media, LLC 2013

  • Hardcover ISBN: 978-1-4614-6463-1Published: 07 May 2013

  • eBook ISBN: 978-1-4614-6464-8Published: 08 July 2014

  • Edition Number: 1

  • Number of Pages: XII, 329

  • Topics: Neurosciences, Neurology, Pharmacology/Toxicology

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access