Biophysics of RNA Folding

  • Rick┬áRussell

Part of the Biophysics for the Life Sciences book series (BIOPHYS, volume 3)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Rick Russell
    Pages 1-10
  3. Namhee Kim, Katherine Niccole Fuhr, Tamar Schlick
    Pages 23-51
  4. Xiaojun Zhang, Peter Z. Qin
    Pages 69-87
  5. Kathleen B. Hall
    Pages 89-116
  6. Barbara L. Golden, Sharon Hammes-Schiffer, Paul R. Carey, Philip C. Bevilacqua
    Pages 135-167
  7. Maithili Saoji, Chun Geng, Paul J. Paukstelis
    Pages 169-186
  8. Michael Brenowitz, Lois Pollack
    Pages 187-203
  9. Pilar Tijerina, Rick Russell
    Pages 205-230
  10. Back Matter
    Pages 231-236

About this book


Structured RNAs are everywhere, functioning throughout gene expression with key roles ranging from catalysis to regulation. New functional RNAs are being discovered all the time; in fact, it is now clear that a much greater fraction of eukaryotic genomes is devoted to coding for RNA than protein. Many of these RNAs must traverse complex energy landscapes to find their functional three-dimensional structures. Along the way, they may encounter native and non-native folding intermediates, chaperone proteins, and assemble with partner proteins.

This volume, written by experts in the field, discusses the current understanding of the biophysical principles that govern RNA folding, with featured RNAs including the ribosomal RNAs, viral RNAs, and self-splicing introns. In addition to the fundamental features of RNA folding, the central experimental and computational approaches in the field are presented with an emphasis on their individual strengths and limitations, and how they can be combined to be more powerful than any method alone; these approaches include NMR, single molecule fluorescence, site-directed spin labeling, structure mapping, comparative sequence analysis, graph theory, course-grained 3D modeling, and more. This volume will be of interest to professional researchers and advanced students entering the field of RNA folding.

Editors and affiliations

  • Rick┬áRussell
    • 1
  1. 1., Dept. of Chemistry and BiochemistryUniversity of TexasAustinUSA

Bibliographic information