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  • Book
  • © 2013

RNA Interference from Biology to Therapeutics

  • Addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches

  • Covers RNAi therapeutic design to optimize siRNA potency and reduce off-target effects

  • Discusses current delivery technologies to overcome both intracellular and extracellular barriers

  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Delivery Science and Technology (ADST)

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eBook USD 219.00
Price excludes VAT (USA)
  • ISBN: 978-1-4614-4744-3
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 279.99
Price excludes VAT (USA)
Hardcover Book USD 279.99
Price excludes VAT (USA)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xv
  2. RNA Interference Pathways and Therapeutic Exploitation

    • Jesper B. Bramsen, Thomas B. Hansen
    Pages 1-29
  3. Synthetic Dicer-Substrate siRNAs as Triggers of RNA Interference

    • Scott D. Rose, Mark A. Behlke
    Pages 31-56
  4. The Role of MicroRNAs in Natural Tissue Development and Application in Regenerative Medicine

    • Morten Østergaard Andersen, Philipp Dillschneider, Jørgen Kjems
    Pages 57-78
  5. Intracellular Delivery Considerations for RNAi Therapeutics

    • Yu Zhu, Jing Li, David Oupický
    Pages 79-95
  6. Mucosal Delivery of RNAi Therapeutics

    • Borja Ballarín González, Ebbe Bech Nielsen, Troels Bo Thomsen, Kenneth A. Howard
    Pages 97-125Open Access
  7. Polymeric Micelles for siRNA Delivery

    • Frederico Pittella, Kazunori Kataoka
    Pages 161-184
  8. RNAi Therapeutic Delivery by Exosomes

    • Samira Lakhal, Samir El Andaloussi, Aisling J. O’Loughlin, Jinghuan Li, Matthew M. J. Wood
    Pages 185-205
  9. Aptamer-Mediated siRNA Targeting

    • Jiehua Zhou, John J. Rossi
    Pages 207-220
  10. RNAi as Antiviral Therapy: The HIV-1 Case

    • Ben Berkhout, Julia J. M. Eekels
    Pages 221-242
  11. The Application of MicroRNAs in Cancer Diagnostics

    • Karina D. Sørensen, Marie S. Ostenfeld, Dennis K. Jeppesen, Helle Kristensen, Christa Haldrup, Torben F. Ørntoft
    Pages 259-298
  12. Therapeutic Application of MicroRNAs in Cancer

    • Nobuyoshi Kosaka, Fumitaka Takeshita, Yusuke Yoshioka, Takahiro Ochiya
    Pages 299-314
  13. Preclinical and Clinical Studies Employing RNA Interference as a Therapeutic for Respiratory Syncytial Virus (RSV) Infection in the Lung

    • Amy R. Simon, Verena Karsten, Rachel Meyers, Jeff Cehelsky, Jared Gollob, Akshay Vaishnaw et al.
    Pages 315-328
  14. Back Matter

    Pages 329-337

About this book

The Nobel Prize winning discovery that small interfering RNA can be utilised to control cellular gene expression has propelled the field of RNA interference (RNAi) to the forefront of biomedical science as a potential molecular medicine set to revolutionalise disease treatment.  

Harnessing the molecular mechanisms of RNAi and development of delivery technologies is crucial for its transformation into a therapeutic modality, this dependency is the focus of “RNA Interference from Biology to Therapeutics” that gives a comprehensive overview of RNAi biology and state-of-the-art delivery methods relevant to clinical translation of RNAi therapeutics.

Key players and shapers in the fields of RNAi and delivery science have been assembled in a single volume to produce a truly unique interdisciplinary text, making it a “must-read” for both students and experts in, and at the interface of, RNAi, pharmaceutical science and medicine. An attractive feature is the “future perspectives” section within each chapter that allows global leaders the opportunity to express their views on the direction the field is moving. Topics covered in the book include miRNA biology and therapeutic exploitation, exosome delivery and clinical translation.

“RNA Interference from Biology to Therapeutics” is an up-to-the-minute, highly informative and invaluable text for those actively involved or interested in this fascinating and high-impact field.

Keywords

  • Gene Silencing
  • MicroRNA
  • Nanomedicine
  • Nanoparticles
  • RNA Interference (RNAi)
  • RNAi Clinical Trials
  • RNAi Therapeutics
  • Small interfering RNA (siRNA)
  • siRNA Delivery

Editors and Affiliations

  • Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark

    Kenneth A. Howard

About the editor

Kenneth Alan Howard is an Associate Professor and Group Leader at the Department of Molecular Biology at the Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Denmark. His team is based in a highly interdisciplinary setting with research and teaching activities focused on advanced drug delivery, nanomedicine, RNA interference, and inflammation. Dr Howard is CEO of an Aarhus University spin-out company that provides delivery solutions for RNA interference-based therapeutics. Kenneth Alan Howard received a PhD in Pharmaceutical Science from the University of Nottingham, UK in 1995, and has held postdoctoral positions at the CRC Institute for Cancer Studies, University of Birmingham, UK and the School of Pharmacy, University of London. Dr Howard is an active member of the Controlled Release Society serving on the Board of Scientific Advisors (chair), Nominations Committee and organizer of a CRS Educational workshop “RNA Interference Biology and Therapeutics”.   

Bibliographic Information

Buying options

eBook USD 219.00
Price excludes VAT (USA)
  • ISBN: 978-1-4614-4744-3
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 279.99
Price excludes VAT (USA)
Hardcover Book USD 279.99
Price excludes VAT (USA)