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Neural-Immune Interactions in Brain Function and Alcohol Related Disorders

  • Book
  • © 2013

Overview

Editors:
  1. Changhai Cui

    1. National Institute on Alcohol Abuse and, Division of Neuroscience and Behavior, NIH, Bethesda, USA

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  2. Lindsey Grandison

    1. National Institute on Alcohol Abuse and, Division of Neuroscience and Behavior, NIH, Bethesda, USA

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  3. Antonio Noronha

    1. National Institute on Alcohol Abuse and, Division of Neuroscience and Behavior, NIH, Bethesda, USA

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  • Provides a comprehensive overview on neuroimmune mechanisms mediating changes in brain function and behavior associated with alcohol drinking
  • Combines emerging knowledge on neural-immune interactions with key discoveries in alcohol research
  • First book to focus on the the interactions between alcohol and the neuroimmune system
  • Includes supplementary material: sn.pub/extras

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About this book

Recent studies have provided clear evidence on the role of neural-immune interactions in normal brain function and neuropathological conditions. Neuroimmune factors, which play an essential role in neuroinflammatory response, have been implicated in the regulation of neuronal function and plasticity. Thus, neural-immune interactions provide a new frame work for understanding the role of the neuroimmune system in normal brain function, neurodevelopment, and a variety of neurological disorders.  These advances have a far reaching impact on many areas of neuroscience, including alcohol research.  Studies using human alcoholic brains, gene knockout mice, and gene expression profiling have established a clear link between alcoholism and an altered neuroimmune profile. This book integrates emerging knowledge on neural-immune interactions with key discoveries in alcohol research and provides a comprehensive overview of neural-immune interactions in brain function and behavior associated with alcohol use disorders. While Neural–Immune Interaction in Brain Function and Alcohol Related Disorders focuses on neural-immune interactions in areas directly related to alcohol use disorders, it is not intended to be all inclusive. Several areas, including sleep disorders, pain, and cholinergic anti-inflammatory pathways, are not covered as independent chapters but briefly mentioned in the text. The close relevance of these topics to neural-immune interactions and alcohol use disorders warrants future discussion and more research efforts.

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-viii
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  2. Neural–Immune Interactions

    1. Front Matter

      Pages 1-1
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  3. Neural-immune Interactions

    1. An Introduction to CNS-Resident Microglia: Definitions, Assays, and Functional Roles in Health and Disease

      • Deirdre S. Davis, Monica J. Carson
      Pages 3-29

    2. Astrocyte–Neuron Communications

      • Sally R. McIver, Mathilde Faideau, Philip G. Haydon
      Pages 31-64

    3. Neuroimmune Modulation of Synaptic Function

      • Horia Pribiag, David Stellwagen
      Pages 65-94

    4. Neuroimaging and Clinical Studies on Brain–Immune Interactions

      • Jonas Hannestad
      Pages 95-132

    5. Mechanisms of Stress-Dependent Neuroinflammation and Their Implications for Understanding Consequences of Alcohol Exposure

      • Terrence Deak, Anny Okrainets, Tamara L. Doremus-Fitzwater
      Pages 133-166

    6. Mood Disorders and Immunity

      • Adam K. Walker, Robert Dantzer, Keith W. Kelley
      Pages 167-209

    7. Neuroimmune Cross Talk and HIV-Associated Neurocognitive Disorders

      • JoEllyn McMillan, Howard E. Gendelman
      Pages 211-248

  4. Alcohol and Neuroimmune Interactions

    1. Front Matter

      Pages 249-249
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    2. Innate Immune Signaling and Alcoholism

      • Ryan P. Vetreno, Fulton T. Crews
      Pages 251-278

    3. Role of Toll-Like Receptor 4 in Alcohol-Induced Neuroinflammation and Behavioral Dysfunctions

      • Consuelo Guerri, María Pascual
      Pages 279-306

    4. Prenatal Alcohol Exposure: Impact on Neuroendocrine–Neuroimmune Networks

      • Tamara Bodnar, Joanne Weinberg
      Pages 307-357

    5. Neuroimmune Mechanisms of Glia and Their Interplay with Alcohol Exposure Across the Lifespan

      • Paul D. Drew, Cynthia J. M. Kane
      Pages 359-386

    6. Alcohol–Chemokine Interaction and Neurotransmission

      • Donna L. Gruol
      Pages 387-424

    7. Neuroimmune Genes and Alcohol Drinking Behavior

      • R. Adron Harris, Yuri A. Blednov
      Pages 425-440

    8. Immune Responses in HIV Infection, Alcoholism, and Aging: A Neuroimaging Perspective

      • N. M. Zahr, A. Manning-Bog, C. Alt, E. V. Sullivan, A. Pfefferbaum
      Pages 441-476

    9. Effects of Morphine and Alcohol on the Hypothalamic–Pituitary–Adrenal Axis, Immunity, and Cognitive Behavior

      • Sulie L. Chang, Xiangqian Liu
      Pages 477-508

    10. Alcohol Abuse, HIV-1, and Hepatitis C Infection

      • Yuri Persidsky, Wen-Zhe Ho, Xu Wang, Raghava Potula
      Pages 509-533

    11. Therapeutic Strategies to Treat Alcohol-Related Disorders Targeting Central Immune Signaling

      • Yue Wu, Mark R. Hutchinson
      Pages 535-559
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Editors and Affiliations

  • National Institute on Alcohol Abuse and, Division of Neuroscience and Behavior, NIH, Bethesda, USA

    Changhai Cui, Lindsey Grandison, Antonio Noronha

Bibliographic Information

  • Book Title: Neural-Immune Interactions in Brain Function and Alcohol Related Disorders

  • Editors: Changhai Cui, Lindsey Grandison, Antonio Noronha

  • DOI: https://doi.org/10.1007/978-1-4614-4729-0

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2013

  • Hardcover ISBN: 978-1-4614-4728-3Published: 25 October 2012

  • Softcover ISBN: 978-1-4899-9578-0Published: 09 November 2014

  • eBook ISBN: 978-1-4614-4729-0Published: 14 November 2012

  • Edition Number: 1

  • Number of Pages: VIII, 588

  • Topics: Neurosciences, Neurochemistry, Immunology

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