A Key Link between Metabolism and Brain Activity

  • Susan Masino
  • Detlev Boison

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Introduction

    1. Front Matter
      Pages 1-1
  3. Molecular Biology, Pharmacology, and Cell Biology of Adenosine

    1. Front Matter
      Pages 21-21
    2. Jaoek Park, Radhey S. Gupta
      Pages 23-54
    3. Xuesong Chen, Liang Hui, Jonathan D. Geiger
      Pages 55-70
    4. Masahito Kawamura Jr., David N. Ruskin
      Pages 71-85
    5. Chris G. Dulla, Susan A. Masino
      Pages 87-107
    6. Stephanie zur Nedden, Alexander S. Doney, Bruno G. Frenguelli
      Pages 109-129
    7. Ana M. Sebastião, Sofia Cristóvão-Ferreira, Joaquim A. Ribeiro
      Pages 131-156
    8. Dustin J. Hines, Philip G. Haydon
      Pages 157-177
    9. Sergi Ferré, César Quiroz, Marco Orrú, Xavier Guitart, Seema Gulyani, Richard Allen et al.
      Pages 179-197
  4. Adenosine Function and Dysfunction in Brain Health and Disease

    1. Front Matter
      Pages 199-199
    2. Tarja Porkka-Heiskanen
      Pages 201-212
    3. Christine Muheim, Steven A. Brown
      Pages 213-232
    4. György Haskó, Balázs Koscsó, Balázs Csóka
      Pages 233-251
    5. Felicita Pedata, Anna Maria Pugliese, Francesca Corti, Alessia Melani
      Pages 273-306
    6. Patrick M. Kochanek, Jonathan D. Verrier, Amy K. Wagner, Edwin K. Jackson
      Pages 307-322

About this book


Homeostasis of key metabolites and metabolic health affects all bodily systems.  Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system – including developmental disorders, acute nervous system injury, and neurodegenerative disorders.  Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions.  Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition. 

Adenosine:  A Key Link Between Metabolism and Central Nervous System Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system.  Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism.  At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression.  Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function.  Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders.  This comprehensive overview of adenosine also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders.

Editors and affiliations

  • Susan Masino
    • 1
  • Detlev Boison
    • 2
  1. 1.Trinity CollegeHartfordUSA
  2. 2.Legacy Research Institute, Portland, OR,PortlandUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-3902-8
  • Online ISBN 978-1-4614-3903-5
  • About this book