A Key Link between Metabolism and Brain Activity

  • Susan Masino
  • Detlev Boison

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Introduction

    1. Front Matter
      Pages 1-1
  3. Molecular Biology, Pharmacology, and Cell Biology of Adenosine

    1. Front Matter
      Pages 21-21
    2. Jaoek Park, Radhey S. Gupta
      Pages 23-54
    3. Xuesong Chen, Liang Hui, Jonathan D. Geiger
      Pages 55-70
    4. Masahito Kawamura Jr., David N. Ruskin
      Pages 71-85
    5. Chris G. Dulla, Susan A. Masino
      Pages 87-107
    6. Stephanie zur Nedden, Alexander S. Doney, Bruno G. Frenguelli
      Pages 109-129
    7. Ana M. Sebastião, Sofia Cristóvão-Ferreira, Joaquim A. Ribeiro
      Pages 131-156
    8. Dustin J. Hines, Philip G. Haydon
      Pages 157-177
    9. Sergi Ferré, César Quiroz, Marco Orrú, Xavier Guitart, Seema Gulyani, Richard Allen et al.
      Pages 179-197
  4. Adenosine Function and Dysfunction in Brain Health and Disease

    1. Front Matter
      Pages 199-199
    2. Tarja Porkka-Heiskanen
      Pages 201-212
    3. Christine Muheim, Steven A. Brown
      Pages 213-232
    4. György Haskó, Balázs Koscsó, Balázs Csóka
      Pages 233-251
    5. Felicita Pedata, Anna Maria Pugliese, Francesca Corti, Alessia Melani
      Pages 273-306
    6. Patrick M. Kochanek, Jonathan D. Verrier, Amy K. Wagner, Edwin K. Jackson
      Pages 307-322
    7. Jana Sawynok
      Pages 343-360
    8. Annalisa Pinna, Nicola Simola, Lucia Frau, Micaela Morelli
      Pages 361-384
    9. David Blum, Ursula Sandau, Cyril Laurent, Vânia Batalha, Antoine Leboucher, Malika Hamdane et al.
      Pages 385-407
    10. David Blum, Alberto Martire, Sylvie Burnouf, Bernard Sablonnière, Pierre Krystkowiak, Catherine Ledent et al.
      Pages 409-434
    11. María Victoria Sánchez-Gómez, Estibaliz González-Fernández, Rogelio O. Arellano, Carlos Matute
      Pages 435-457
    12. Benjamin K. Yee, Philipp Singer, Detlev Boison
      Pages 459-491
    13. Julia Svedova, Inge-Marie Eigsti, Susan A. Masino
      Pages 513-533
    14. Traci N. Plumb, Sarah R. Sterlace, Kelly A. Cavanaugh, Thomas R. Minor
      Pages 535-558
  5. Adenosine-Based Therapies

    1. Front Matter
      Pages 559-559
    2. Jong M. Rho, Beth Zupec-Kania, Susan A. Masino
      Pages 581-598
    3. Eleanor M. Pritchard, Detlev Boison, David L. Kaplan
      Pages 599-620
  6. Back Matter
    Pages 657-679

About this book


Homeostasis of key metabolites and metabolic health affects all bodily systems.  Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system – including developmental disorders, acute nervous system injury, and neurodegenerative disorders.  Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions.  Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition. 

Adenosine:  A Key Link Between Metabolism and Central Nervous System Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system.  Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism.  At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression.  Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function.  Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders.  This comprehensive overview of adenosine also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders.

Editors and affiliations

  • Susan Masino
    • 1
  • Detlev Boison
    • 2
  1. 1.Trinity CollegeHartfordUSA
  2. 2.Legacy Research Institute, Portland, OR,PortlandUSA

Bibliographic information