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LC-MS in Drug Bioanalysis

  • Q. Alan Xu
  • Timothy L. Madden

Table of contents

  1. Front Matter
    Pages i-xi
  2. Aimin Tan, Nadine Boudreau, Ann Lévesque
    Pages 1-32
  3. Christoph Seger, Michael Vogeser
    Pages 109-126
  4. Alan H. B. Wu, Kara L. Lynch
    Pages 127-141
  5. Eva Saar, Dimitri Gerostamoulos, Olaf H. Drummer, Jochen Beyer
    Pages 177-195
  6. Laurent Decosterd, Elyes Dahmane, Marine Neeman, Thierry Buclin, Chantal Csajka, Amina Haouala et al.
    Pages 197-250
  7. Zimeng Yan, Chang Cheng, Shaorong Liu
    Pages 251-286
  8. Manuel Sergi, Sabino Napoletano
    Pages 349-398
  9. Jörg Müller, Grigoriy Quiring, Maria Reinhardt-Szyba, Régulo Miguel Ramírez Wong, Henning Wehrs
    Pages 423-465
  10. Back Matter
    Pages 467-469

About this book

Introduction

            High performance liquid chromatography – mass spectrometry (LC-MS) combines the separation power of liquid chromatography with the high sensitivity and selectivity of mass spectrometry. Therefore, LC-MS becomes the method of choice for drug bioanalysis in therapeutic drug monitoring, toxicology, and drug discovery and development. LC-MS in Drug Bioanalysis offers discussions on:

            ● LC-MS/MS method development and validation in a regulated environment

            ● Internal standard use in LC-MS/MS bioanalysis

            ● Pitfalls of LC-MS/MS and how to overcome them

            ● Dried blood spot sampling

            ● Microflow LC-MS/MS

            ● LC-MS/MS in therapeutic drug monitoring

            ● Applications of LC-MS/MS in drug bioanalysis

This book will aid readers to improve their skills in LC-MS/MS method development, validation, and applications in the analysis of drugs and their metabolites in complex biological matrices.  In addition, this book provides detailed information on the bioanalysis of antidepressants, antipsychotics, steroid hormones, anticancer agents, and drugs of abuse. Newer methodologies are discussed including the use of unique sample preparation techniques and the implementation of imaging mass spectrometry in the localization of drug and drug metabolites in tissues.

Keywords

Bioanalysis LC-MS LC-MS/MS Liquid chromatography MS anticancer drugs antidementia drugs antidepressants antiepileptic drugs antifundal drugs antimicrobial drugs antipsychotic drugs antiretroviral Drugs anxiolytic/hypnotic drugs cardiac drugs drugs for addiction immunosuppressants mass spectrometry metabolites mood stabilizers

Editors and affiliations

  • Q. Alan Xu
    • 1
  • Timothy L. Madden
    • 2
  1. 1., Department of Experimental TherapeuticsUniversity of Texas MD Anderson Cancer CHoustonUSA
  2. 2., Department of Experimental TherapeuticsUniversity of Texas MD Anderson Cancer CHoustonUSA

Bibliographic information