Emerging Concepts of Tumor Exosome–Mediated Cell-Cell Communication

  • Huang-Ge Zhang

Table of contents

  1. Front Matter
    Pages 1-1
  2. Alessandra Lo Cicero, Graça Raposo
    Pages 1-32
  3. Cecilia Lässer, Maria Eldh, Jan Lötvall
    Pages 33-45
  4. Sanyukta Rana, Margot Zöller
    Pages 69-106
  5. Douglas D. Taylor, Gercel-Taylor Cicek
    Pages 131-148
  6. Huang-Ge Zhang, Johan K. O. Skog
    Pages 169-179
  7. Haiying Zhang, Guillermo Garcia-Santos, Héctor Peinado, David C. Lyden
    Pages 181-201
  8. Mariusz Z. Ratajczak, Kasia Mierzejewska, Magda Kucia, Nick Greco, Janina Ratajczak
    Pages 203-216
  9. Back Matter
    Pages 214-214

About this book

Introduction

Tumor exsome-mediated cell-cell communication has grown increasingly important in cancer research. Recent findings on vesicle-based information transfer by exosomes have changed our view of the tumor microenvironment.  Currently, exosomes represent the main extracellular processes implicated in the regulation of multiple physiological processes. Importantly, in cancer, exosomes contribute to the formation of the tumor microenvironment, promoting invasion, angiogenesis, immune regulation and metastasis. Therefore, exosomes could be considered one of the major forces acting locally or systemically to promote the continuous crosstalk between the tumor and its microenvironment, influencing the behavior of different cell types such as stromal, endothelial and bone marrow-derived cells.

Given the ability of exosomes to export unneeded endogenous molecules from cells, these structures hold great potential as anticancer therapeutic agents. This volume gives a comprehensive review on current research in this area and also discuss future prospects as prognostic markers for cancer.

Keywords

esRNA exosomal shuttle RNA exosomes metastasis by exosomes tetraspanins

Editors and affiliations

  • Huang-Ge Zhang
    • 1
  1. 1., James Brown Cancer CenterUniversity of LouisvilleLouisvilleUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-3697-3
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-3696-6
  • Online ISBN 978-1-4614-3697-3
  • About this book