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  • Book
  • © 2012

Computational Modeling of Biological Systems

From Molecules to Pathways

  • Reviews established modeling approaches of biological systems across multiple length and time scales from molecules to cells

  • Covers recent and emerging computational techniques in modelling biological systems

  • Provides a fresh outlook on the topic by covering multiscale modelling and includes a section on molecular evolution

  • Can be used as a guide for selecting methods for studying biological systems

  • Includes supplementary material: sn.pub/extras

Part of the book series: Biological and Medical Physics, Biomedical Engineering (BIOMEDICAL)

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eBook USD 109.00
Price excludes VAT (USA)
  • ISBN: 978-1-4614-2146-7
  • Instant PDF download
  • Readable on all devices
  • Own it forever
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  • Tax calculation will be finalised during checkout
Softcover Book USD 139.99
Price excludes VAT (USA)
Hardcover Book USD 179.99
Price excludes VAT (USA)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-vi
  2. Molecular Modeling

    1. Front Matter

      Pages 1-1
    2. Discrete Molecular Dynamics Simulation of Biomolecules

      • Feng Ding, Nikolay V. Dokholyan
      Pages 55-73
    3. Small Molecule Docking from Theoretical Structural Models

      • Eva Maria Novoa, Lluis Ribas de Pouplana, Modesto Orozco
      Pages 75-95
  3. Modeling Macromolecular Assemblies

    1. Front Matter

      Pages 165-165
    2. Multiscale Modeling of Virus Structure, Assembly, and Dynamics

      • Eric R. May, Karunesh Arora, Ranjan V. Mannige, Hung D. Nguyen, Charles L. Brooks III
      Pages 167-189
  4. Modeling Cells and Cellular Pathways

    1. Front Matter

      Pages 229-229
    2. Computer Simulations of Mechano-Chemical Networks Choreographing Actin Dynamics in Cell Motility

      • Pavel I. Zhuravlev, Longhua Hu, Garegin A. Papoian
      Pages 231-256
    3. Computational and Modeling Strategies for Cell Motility

      • Qi Wang, Xiaofeng Yang, David Adalsteinsson, Timothy C. Elston, Ken Jacobson, Maryna Kapustina et al.
      Pages 257-296
  5. Modeling Evolution

    1. Front Matter

      Pages 309-309
    2. Modeling Protein Evolution

      • Richard Goldstein, David Pollock
      Pages 311-325
    3. Modeling Proteins at the Interface of Structure, Evolution, and Population Genetics

      • Ashley I. Teufel, Johan A. Grahnen, David A. Liberles
      Pages 347-361

About this book

Computational modeling is emerging as a powerful new approach for studying and manipulating biological systems. Many diverse methods have been developed to model, visualize, and rationally alter these systems at various length scales, from atomic resolution to the level of cellular pathways. Processes taking place at larger time and length scales, such as molecular evolution, have also greatly benefited from new breeds of computational approaches.

Computational Modeling of Biological Systems: From Molecules to Pathways provides an overview of established computational methods for the modeling of biologically and medically relevant systems. It is suitable for researchers and professionals working in the fields of biophysics, computational biology, systems biology, and molecular medicine.

Keywords

  • biological physics
  • computational biology
  • computational modeling
  • molecular medicine
  • molecular modeling
  • systems biology

Editors and Affiliations

  • , Biochemistry and Biophysics, University of North Carolina at Chapel H, Chapel Hill, USA

    Nikolay V Dokholyan

About the editor

Dr. Nikolay Dokholyan joined the Department of Biochemistry and Biophysics in the University of North Carolina at Chapel Hill, School of Medicine as an Assistant Professor. In 2008, Dr. Dokholyan was promoted as Associate Professor. Dr. Dokholyan is currently the Director of the Center for Computational and Systems Biology and the Graduate Director of the Program in Molecular and Cellular Biophysics at UNC.

Bibliographic Information

Buying options

eBook USD 109.00
Price excludes VAT (USA)
  • ISBN: 978-1-4614-2146-7
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 139.99
Price excludes VAT (USA)
Hardcover Book USD 179.99
Price excludes VAT (USA)