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Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants

New Vistas In Parkinson's Disease Therapy

  • Lucyna Antkiewicz-Michaluk
  • Hans Rommelspacher

Part of the Current Topics in Neurotoxicity book series (Current Topics Neurotoxicity, volume 1)

Table of contents

  1. Front Matter
    Pages i-x
  2. Isoquinolines as Neurotoxins and Neuroprotectants

  3. β-Carbolines as Neurotoxins and Neuroprotectants

    1. Front Matter
      Pages 75-75
    2. Tomás Herraiz
      Pages 77-103
    3. Hans Rommelspacher, Catrin Wernicke, Jochen Lehmann
      Pages 105-113
    4. Hans Rommelspacher, Monika Frenzel, Norbert A. Dencher
      Pages 125-131
    5. Jochen Lehmann
      Pages 133-144
    6. Hans Rommelspacher, Catrin Wernicke
      Pages 145-164
  4. Back Matter
    Pages 173-177

About this book

Introduction

This book summarizes, for the first time, the results from behavioral, neurochemical and molecular experiments, which demonstrate a wide spectrum of tetrahydroisoquinolines (TIQs) and beta-carbolines (BCs) effects - from their rather mild neurotoxic actions to the important neuroprotective and antiaddictive properties.  Additionally, the recent results of experimental studies in vivo have allowed a much better understanding and simultaneous comparison of the neurochemical and molecular mechanisms underlying the neuroprotective and neurotoxic actions of endogenous TIQs and BCs and have pointed to the possibility of their therapeutic applications in neurodegenerative diseases such as Parkinson's disease.

The specific topic, Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants – New Perspectives In Parkinson's Disease Therapy, was chosen in light of accumulating neurobiological evidence indicating that, in addition to exogenous neurotoxins (e.g., 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [MPTP]), endogenous compounds may play an important role in the most common neurodegenerative disorders (e.g., Parkinson's disease). Two groups of amine related compounds, which appeared chemically like MPTP, were detected in human brain and cerebrospinal fluid (CSF): BCs and TIQs. These are heterocyclic compounds formed endogenously from phenylalanine/tyrosine (TIQs) and tryptophan, tryptamine, and 5-hydroxytryptamine (BCs), respectively, and exert a wide spectrum of psychopharmacological and behavioral effects. The TIQs and BCs may bind to their own high affinity sites on neuronal membranes associated with or located close to the receptors of neurotransmitters. Research on TIQs and BCs is stimulated also by their possible role in pathological conditions, especially parkinsonism and alcoholism. Recently, clinical interest has been spurred by their role as neuroprotective, and even neurorestorative, anticonvulsant and antiaddictive, substances.

Editors and affiliations

  • Lucyna Antkiewicz-Michaluk
    • 1
  • Hans Rommelspacher
    • 2
  1. 1.KrakowPoland
  2. 2., Departments of PsychiatryCharité-University MedicineBerlinGermany

Bibliographic information