Fundamentals and Applications of Controlled Release Drug Delivery

  • Juergen Siepmann
  • Ronald A. Siegel
  • Michael J. Rathbone

Part of the Advances in Delivery Science and Technology book series (ADST)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. The Value of Drug Delivery

    1. Front Matter
      Pages 1-1
    2. Ronald A. Siegel, Michael J. Rathbone
      Pages 19-43
  3. Delivery Materials

    1. Front Matter
      Pages 45-45
    2. Osama A. Abu-Diak, Gavin P. Andrews, David S. Jones
      Pages 47-73
    3. Hossein Omidian, Kinam Park
      Pages 75-105
    4. Jamie Tsung, Diane J. Burgess
      Pages 107-123
  4. Temporal Delivery Systems and Mechanisms

    1. Front Matter
      Pages 125-125
    2. Juergen Siepmann, Ronald A. Siegel, Florence Siepmann
      Pages 127-152
    3. Juergen Siepmann, Florence Siepmann
      Pages 153-170
    4. C. Wischke, S. P. Schwendeman
      Pages 171-228
    5. Ronald A. Siegel
      Pages 229-251
  5. Spatial Delivery Systems and Mechanisms

    1. Front Matter
      Pages 253-253
    2. Elias Fattal, Hervé Hillaireau, Simona Mura, Julien Nicolas, Nicolas Tsapis
      Pages 255-288
    3. Vladimir Torchilin
      Pages 289-328
  6. Applications

    1. Front Matter
      Pages 357-357
    2. Michael H. Smolensky, Ronald A. Siegel, Erhard Haus, Ramon Hermida, Francesco Portaluppi
      Pages 359-443
    3. Ilia Fishbein, Michael Chorny, Ivan S. Alferiev, Robert J. Levy
      Pages 445-492
    4. Vivekanand Bhardwaj, M. N. V. Ravi Kumar
      Pages 493-516
    5. Charles T. Drinnan, Laura R. Geuss, Ge Zhang, Laura J. Suggs
      Pages 533-568
  7. Future Outlook

  8. Back Matter
    Pages 579-592

About this book


This authoritative book covers the fundamentals relating to the science and technology of drug delivery.  The book is written at a level that is understandable to those entering the field and who are not familiar with its common phrases or complex terms.  It is a book that provides a simple encapsulation of concepts and expands on them using a building block approach to each subject, starting at a basic level and building to extend the readers knowledge and application of the subject.  In each chapter the basic concept is explained as simply and clearly as possible without a great deal of detail, then in subsequent sections additional material is introduced in order to build up the reader’s understanding and comprehension of the subject matter.


The book comprises several Parts.  The first part covers the fundamentals of drug delivery, the second covers delivery materials, the third deals with delivery systems (both temporal and spatial) and the fourth introduces the reader to some clinical applications of drug delivery. The book ends with a future outlook chapter in which prospects for the field are envisioned.


This book will be indispensible to scientists interested in the science and technology of drug delivery and be essential for those developing delivery systems designed to improve the clinical performance of a drug.


Professor Juergen Siepmann is Professor of Pharmaceutics at the College of Pharmacy, Université Lille Nord de France, Lille, France. He studied pharmacy and received his doctoral degree from the Freie Universitaet Berlin, Berlin, Germany, in 1999. His research focuses on the elucidation of the underlying mass transport phenomena in controlled drug delivery systems. Prof. Siepmann is reviews editor of the International Journal of Pharmaceutics and president of APGI (French Association of Pharmaceutical Technology). Since 2010 he is heading the INSERM (French National Institute of Health and Medical Research) research group “Controlled Drug Delivery Systems and Biomaterials”.



Ronald A. Siegel, Sc.D., is Professor of Pharmaceutics and Biomedical Engineering at the University of Minnesota.  He received his doctoral degree from MIT under the direction of Prof. Robert Langer in 1984, and taught at the University of California, San Francisco until 1998, when he moved to Minnesota.  Professor Siegel is Fellow of the Controlled Release Society (CRS), the American Association of Pharmaceutical Scientists, and the American Institute of Medical and Biological Engineering.  He was president of CRS from 1997-1998.  His present research interests include hydrogels, block polymers, microfabricated sensors and drug delivery systems, and mathematical modeling of transport.



Michael J. Rathbone is Associate Professor of Pharmaceutics at the School of Pharmacy, Griffith University, Australia.  Dr. Rathbone’s research interests are in the modified delivery of bioactives to the mouth, polymeric delivery systems and long acting veterinary drug delivery systems.  He is a Fellow of the Controlled Release Society (CRS) and received the CRS Distinguished Service Award in 2006.  He has edited or co-edited many books in the fields of modified release drug delivery, oral mucosal drug delivery and veterinary drug delivery.


Application Application Controlled Controlled Delivery Delivery Drug Fundamental Rathbone Release Release Science Siegel Siepmann Technology

Editors and affiliations

  • Juergen Siepmann
    • 1
  • Ronald A. Siegel
    • 2
  • Michael J. Rathbone
    • 3
  1. 1.PhalempinFrance
  2. 2., Department of PharmaceuticsUniversity of MinnesotaMinneapolisUSA
  3. 3., School of PharmacyGriffith UniversitySouthportAustralia

Bibliographic information