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  • Book
  • © 2012

Long Acting Injections and Implants

Editors:

(view affiliations)
  • Provides a comprehensive overview of the scientific and regulatory challenges

  • Gives description of the types of systems, major areas of current application and research together with current commercial applications

  • The reader is introduced to the host response to biomaterials/foreign body and the influence of environmental conditions on the design and development of long acting injections and implants

  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Delivery Science and Technology (ADST)

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USD 179.00
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  • ISBN: 978-1-4614-0554-2
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  • Own it forever
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  • Tax calculation will be finalised during checkout
Softcover Book
USD 229.99
Price excludes VAT (USA)
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Table of contents (24 chapters)

  1. Front Matter

    Pages i-xv
  2. An Introduction to Long Acting Injections and Implants

    • Diane J. Burgess, Jeremy C. Wright
    Pages 1-9
  3. Historical Overview of Long Acting Injections and Implants

    • Jeremy C. Wright, Allan S. Hoffman
    Pages 11-24
  4. Drugs for Long Acting Injections and Implants

    • Jie Shen, Diane J. Burgess
    Pages 73-91
  5. Diseases and Clinical Applications that Can Benefit from Long Lasting Implants and Injections

    • Roshan James, Udaya S. Toti, Sangamesh G. Kumbar, Cato T. Laurencin
    Pages 93-111
  6. Oily (Lipophilic) Solutions and Suspensions

    • Susan W. Larsen, Mette A. Thing, Claus Larsen
    Pages 113-135
  7. Aqueous Suspensions

    • Susan M. Machkovech, Todd P. Foster
    Pages 137-151
  8. In Situ Forming Systems (Depots)

    • Jeremy C. Wright, Michael Sekar, William van Osdol, Huey Ching Su, Andrew R. Miksztal
    Pages 153-166
  9. Microsphere Technologies

    • Yan Wang, Diane J. Burgess
    Pages 167-194
  10. Liposomes as Carriers for Controlled Drug Delivery

    • Xiaoming Xu, Diane J. Burgess
    Pages 195-220
  11. Micro- and Nanoemulsions (Controlled Release Parenteral Drug Delivery Systems)

    • Jacqueline M. Morais, Diane J. Burgess
    Pages 221-238
  12. Nanosuspensions

    • Sumit Kumar, Diane J. Burgess
    Pages 239-261
  13. PEGylated Pharmaceutical Nanocarriers

    • Vladimir Torchilin
    Pages 263-293
  14. Protein PEGylation

    • Francesco M. Veronese, Gianfranco Pasut
    Pages 295-313
  15. Self-Assembling Lipid Formulations

    • Fredrik Tiberg, Markus Johnsson, Catalin Nistor, Fredrik Joabsson
    Pages 315-333
  16. Implantable Drug Delivery Systems Based on the Principles of Osmosis

    • John A. Culwell, Jose R. Gadea, Clarisa E. Peer, Jeremy C. Wright
    Pages 335-357
  17. Microtechnologies for Drug Delivery

    • Kristy M. Ainslie, Tejal A. Desai
    Pages 359-381
  18. Drug-Eluting Stents

    • Jonathon Zhao, Lori Alquier
    Pages 383-407

About this book

Long acting injections and implants improve therapy, enhance patient compliance, improve dosing convenience, and are the most appropriate formulation choice for drugs that undergo extensive first pass metabolism or that exhibit poor oral bioavailability.  An intriguing variety of technologies have been developed to provide long acting injections and implants.  Many considerations need to go into the design of these systems in order to translate a concept from the lab bench to actual therapy for a patient.  This book surveys and summarizes the field. 

Topics covered in Long Acting Injections and Implants include the historical development of the field, drugs, diseases and clinical applications for long acting injections and implants, anatomy and physiology for these systems, specific injectable technologies (including lipophilic solutions, aqueous suspensions, microspheres, liposomes, in situ forming depots and self-assembling lipid formulations), specific implantable technologies (including osmotic implants, drug eluting stents and microfabricated systems), peptide, protein and vaccine delivery, sterilization, drug release testing and regulatory aspects of long acting injections and implants.

This volume provides essential information for experienced development professionals but was also written to be useful for scientists just beginning work in the field and for others who need an understanding of long acting injections and implants.  This book will also be ideal as a graduate textbook.

Dr. Jeremy Wright is a Principal Engineer at the DURECT Corporation in Cupertino, California.  He has over 30 years of experience in the development of drug delivery systems.  He has been a key contributor to the development of implantable osmotic systems for veterinary and human use (DUROS®) and is currently involved in research and development of injectable depot systems.  Dr. Wright is the inventor on over 50 patents.

 

Dr. Diane J. Burgess is Distinguished Professor of Pharmaceutics, at the University of Connecticut.  Her research efforts focus on gene and drug delivery and she has over 140 refereed publications. Dr. Burgess was the 2010 President of the Controlled Release Society (CRS), the 2002 President of the American Association of Pharmaceutical Scientists (AAPS) and is a CRS, AAPS and an American Institute for Medical and Biological Engineering (AIMBE) fellow.  She  is editor of the International Journal of Pharmaceutics.

Keywords

  • Acting
  • Burgess
  • Controlled
  • Delivery
  • Implant
  • Injection
  • Long
  • Rathbone
  • Release
  • Science
  • Society
  • Technology
  • Wright

Editors and Affiliations

  • Los Altos, USA

    Jeremy C. Wright

  • Storrs, USA

    Diane J. Burgess

About the editors

Dr. Jeremy Wright is a Principal Engineer at the DURECT Corporation in Cupertino, California.  He has over 30 years of experience in the development of drug delivery systems.  He has been a key contributor to the development of implantable osmotic systems for veterinary and human use (DUROS®) and is currently involved in research and development of injectable depot systems.  Dr. Wright is the inventor on over 50 patents.

 

Dr. Diane J. Burgess is Distinguished Professor of Pharmaceutics, at the University of Connecticut.  Her research efforts focus on gene and drug delivery and she has over 140 refereed publications. Dr. Burgess was the 2010 President of the Controlled Release Society (CRS), the 2002 President of the American Association of Pharmaceutical Scientists (AAPS) and is a CRS, AAPS and an American Institute for Medical and Biological Engineering (AIMBE) fellow.  She  is editor of the International Journal of Pharmaceutics.

Bibliographic Information

Buying options

eBook
USD 179.00
Price excludes VAT (USA)
  • ISBN: 978-1-4614-0554-2
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 229.99
Price excludes VAT (USA)
Hardcover Book
USD 299.99
Price excludes VAT (USA)