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DNA Topoisomerases and Cancer

  • Yves Pommier

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Patrick Forterre
    Pages 1-52
  3. Ilaria Dalla Rosa, Yves Pommier, Hongliang Zhang
    Pages 71-85
  4. James M. Berger, Neil Osheroff
    Pages 87-101
  5. Stefanie Hartman Chen, Jianhong Wu, Tao-shih Hsieh
    Pages 103-117
  6. Céline Auzanneau, Philippe Pourquier
    Pages 119-143
  7. Yves Pommier, Neil Osheroff
    Pages 145-154
  8. Mounira Amor-Guéret, Jean-François Riou
    Pages 155-173
  9. Christophe Marchand, Yves Pommier
    Pages 175-184
  10. Beverly A. Teicher
    Pages 185-210
  11. Anna Rogojina, Stefan Gajewski, Karim Bahmed, Neil Osheroff, John L. Nitiss
    Pages 211-243
  12. Yan Makeyev, Franco Muggia, Arun Rajan, Giuseppe Giaccone, Takahisa Furuta, Philippe Rougier
    Pages 245-277
  13. Olivier Mir, William Dahut, François Goldwasser, Christopher Heery
    Pages 279-307
  14. Giovanni Capranico, Laura Baranello, Davide Bertozzi, Jessica Marinello
    Pages 309-324
  15. Thomas S. Dexheimer, Shar-yin N. Huang, Benu Brata Das, Yves Pommier
    Pages 335-354
  16. John L. Nitiss, Eroica Soans, Jeffrey Berk, Aman Seth, Margarita Mishina, Karin C. Nitiss
    Pages 381-407
  17. Olivier Sordet, Stéphanie Solier
    Pages 409-435
  18. Back Matter
    Pages 437-443

About this book

Introduction

DNA topoisomerases are present in all living organisms and are essential to maintaining the helical structure of DNA. They are highly relevant for cancer because a number of anti-cancer drugs selectively target two of the human enzymes, DNA topoisomerases I and II. Those drugs convert topoisomerases into cellular poisons by trapping the enzymes as they cleave DNA. The book starts out with a detailed outline of the phyllogeny of the different topoisomerases, continues with recent studies on the crystal structures of the human topoisomerases, and their biochemistry. The following section reviews the chemical biology of the topoisomerase inhibitors used in cancer chemotherapy and the implication of topoisomerases in generating recombinations and DNA damage. The third section summarizes the current use of the various topoisomerase inhibitors in cancer chemotherapy. And finally, the last section includes several chapters describing the DNA repair pathways for topoisomerase-induced DNA damage. This book is intended for students and faculty but also for health care professionals who wish to have a self-contained and up-to-date information on topoisomerases. Chapters have been written by leaders and world reknowned experts in the topoisomerase field.

Keywords

Tyrosyl-DNA-Phosphodiesterase Ubiquitin antigens camptothecins transcriptional stress

Editors and affiliations

  • Yves Pommier
    • 1
  1. 1.Laboratory of Molecular PharmacologyNational Institutes of Health Laboratory of Molecular PharmacologyBethesdaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-0323-4
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine
  • Print ISBN 978-1-4614-0322-7
  • Online ISBN 978-1-4614-0323-4
  • Series Print ISSN 2196-9906
  • Series Online ISSN 2196-9914
  • Buy this book on publisher's site