Functional Coherence of Molecular Networks in Bioinformatics

  • Mehmet Koyutürk
  • Shankar Subramaniam
  • Ananth Grama

Table of contents

  1. Front Matter
    Pages i-x
  2. Mehmet Koyutürk, Shankar Subramaniam, Ananth Grama
    Pages 1-13
  3. Tijana Milenković, Nataša Pržulj
    Pages 15-48
  4. Petko Bogdanov, Kathy Macropol, Ambuj K. Singh
    Pages 49-67
  5. Phuong Dao, Fereydoun Hormozdiari, Iman Hajirasouliha, Martin Ester, S. Cenk Sahinalp
    Pages 69-95
  6. Shahin Mohammadi, Ananth Grama
    Pages 97-136
  7. Wenyuan Li, Haiyan Hu, Yu Huang, Haifeng Li, Michael R. Mehan, Juan Nunez-Iglesias et al.
    Pages 137-170
  8. Mehmet Koyutürk, Sinan Erten, Salim A. Chowdhury, Rod K. Nibbe, Mark R. Chance
    Pages 171-199
  9. Back Matter
    Pages 221-228

About this book


A fundamental problem in life sciences is the characterization of biological function. In medical sciences, understanding the bases of functional anomalies holds the key to effective diagnosis, treatment,  and prognosis; in genetics, functional annotation of genetic variability uncovers the complex relationship between genotype and phenotype; in evolutionary biology, functional differences between diverse organisms highlight the evolutionary mechanisms that underlie the complexity of biological systems. With the successful completion of the human genome project and recent technological advances in biological data collection, it has become possible to study biological function from a systems perspective. Today, Systems Biology is established as a fundamental interdisciplinary science, which focuses on systematic study of the complex mechanisms that orchestrate the cooperation between diverse molecules that compose life.

In the study of biological systems, the complex interactions between biomolecules are often abstracted using network models. Molecular networks provide descriptions of the organization of various biological processes, including cellular signaling, metabolism, and genetic regulation. Knowledge on molecular networks provides the basis for systems level analysis of biological function. Research and method development for such analyses has grown tremendously in the past few years. This volume provides a detailed overview of existing knowledge on the functional characterization of biological networks. In eight chapters authored by an international group of systems biology and bioinformatics researchers, functional coherence of molecular networks is comprehensively explored from various perspectives, including network topology, modularity, functional inference, evolution, phenotype, disease, network dynamics, and molecular kinetics.

Editors and affiliations

  • Mehmet Koyutürk
    • 1
  • Shankar Subramaniam
    • 2
  • Ananth Grama
    • 3
  1. 1.Department of Electrical Engineering & CCase Western Reserve UniversityClevelandUSA
  2. 2.Department of BioengineeringUniversity of California, San DiegoLa JollaUSA
  3. 3.Department of Computer SciencePurdue UniversityWest LafayetteUSA

Bibliographic information