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HLA and Disease Associations

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  • © 1985


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Table of contents (24 chapters)


About this book

The human leukocyte antigen (HLA) or tissue types are the products of a rapidly developing field of knowledge within the last 20 years. In the early stages of the research many investigators suspected the existence of a complex series of transplantation antigens, but it was widely believed that these antigens would not be well-defined even in this century. Yet in the last two decades as many as 124 different HLA antigens determined by at least 7 very closely linked genes located on the short arm of chromosome 6 have been identified and subsequently agreed upon by an international nomenclature committee. 1 Extensive international collaboration fueled by the potential clinical application of these antigens to clinical transplantation has advanced the field rapidly. There were nine inter­ national histocompatibility workshops held during this period. Although iden­ tification of HLA antigens was of primary clinical importance in transplantation 2 and of great basic interest in human genetics and anthropology, a rather un­ expected bonus has been the determination that HLA antigens are associated with disease susceptibility to a greater extent than any other known genetic marker in man. In the past, many genetic polymorphisms have been suspected to be associated with diseases. The most extensively studied markers are blood groups, enzymes, and serum proteins. A comprehensive account of published studies, totalling approximately 1,000, of these markers is available in a book by Mourant et al.

Authors and Affiliations

  • Center for The Health Sciences, UCLA Tissue Typing Laboratory, Los Angeles, USA

    Jawahar L. Tiwari

  • UCLA Hospital and Clinics, Los Angeles, USA

    Paul I. Terasaki

Bibliographic Information

  • Book Title: HLA and Disease Associations

  • Authors: Jawahar L. Tiwari, Paul I. Terasaki

  • DOI:

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag New York, Inc. 1985

  • Softcover ISBN: 978-1-4613-8547-9Published: 09 November 2011

  • eBook ISBN: 978-1-4613-8545-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 472

  • Topics: Allergology, Immunology, Human Genetics

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