HLA and Disease Associations

  • Jawahar L. Tiwari
  • Paul I. Terasaki

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. Jawahar L. Tiwari, Paul I. Terasaki
    Pages 1-3
  3. Jawahar L. Tiwari, Paul I. Terasaki
    Pages 4-17
  4. Jawahar L. Tiwari, Paul I. Terasaki
    Pages 18-27
  5. Jawahar L. Tiwari, Paul I. Terasaki
    Pages 28-31
  6. Jawahar L. Tiwari, Paul I. Terasaki
    Pages 32-48
  7. Jawahar L. Tiwari, Paul I. Terasaki
    Pages 49-111
  8. Jawahar L. Tiwari, Paul I. Terasaki
    Pages 112-151
  9. Jawahar L. Tiwari, Paul I. Terasaki
    Pages 152-184
  10. Jawahar L. Tiwari, Paul I. Terasaki
    Pages 185-231
  11. Jawahar L. Tiwari, Paul I. Terasaki
    Pages 232-263
  12. Jawahar L. Tiwari, Paul I. Terasaki
    Pages 264-276
  13. Jawahar L. Tiwari, Paul I. Terasaki
    Pages 277-321
  14. Jawahar L. Tiwari, Paul I. Terasaki
    Pages 322-334
  15. Jawahar L. Tiwari, Paul I. Terasaki
    Pages 335-351
  16. Jawahar L. Tiwari, Paul I. Terasaki
    Pages 352-362
  17. Jawahar L. Tiwari, Paul I. Terasaki
    Pages 363-378
  18. Jawahar L. Tiwari, Paul I. Terasaki
    Pages 379-382
  19. Jawahar L. Tiwari, Paul I. Terasaki
    Pages 383-401
  20. Jawahar L. Tiwari, Paul I. Terasaki
    Pages 402-403

About this book

Introduction

The human leukocyte antigen (HLA) or tissue types are the products of a rapidly developing field of knowledge within the last 20 years. In the early stages of the research many investigators suspected the existence of a complex series of transplantation antigens, but it was widely believed that these antigens would not be well-defined even in this century. Yet in the last two decades as many as 124 different HLA antigens determined by at least 7 very closely linked genes located on the short arm of chromosome 6 have been identified and subsequently agreed upon by an international nomenclature committee. 1 Extensive international collaboration fueled by the potential clinical application of these antigens to clinical transplantation has advanced the field rapidly. There were nine inter­ national histocompatibility workshops held during this period. Although iden­ tification of HLA antigens was of primary clinical importance in transplantation 2 and of great basic interest in human genetics and anthropology, a rather un­ expected bonus has been the determination that HLA antigens are associated with disease susceptibility to a greater extent than any other known genetic marker in man. In the past, many genetic polymorphisms have been suspected to be associated with diseases. The most extensively studied markers are blood groups, enzymes, and serum proteins. A comprehensive account of published studies, totalling approximately 1,000, of these markers is available in a book by Mourant et al.

Keywords

Antigen Chromosom DNA Retinoblastom Termination Xeroderma pigmentosum asthma genes genetics infectious disease interferon transplantation

Authors and affiliations

  • Jawahar L. Tiwari
    • 1
  • Paul I. Terasaki
    • 2
  1. 1.Center for The Health SciencesUCLA Tissue Typing LaboratoryLos AngelesUSA
  2. 2.UCLA Hospital and ClinicsLos AngelesUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4613-8545-5
  • Copyright Information Springer-Verlag New York 1985
  • Publisher Name Springer, New York, NY
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-8547-9
  • Online ISBN 978-1-4613-8545-5
  • About this book