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Biological Reactive Intermediates

Formation, Toxicity, and Inactivation

  • David J. Jollow
  • James J. Kocsis
  • Robert Snyder
  • Harri Vainio
  • Jussi Saukkonen
  • Charlotte Witmer
  • Thomas Walle

Table of contents

  1. Front Matter
    Pages i-xi
  2. Reactive Intermediates in Toxicology and Carcinogenesis: Role of Covalent Binding

    1. Front Matter
      Pages 1-1
    2. David J. Jollow, James J. Kocsis, Robert Snyder, Harri Vainio, Jussi Saukkonen, Charlotte Witmer et al.
      Pages 60-61
  3. Formation of Reactive Intermediates

    1. Front Matter
      Pages 63-63
    2. David J. Jollow, James J. Kocsis, Robert Snyder, Harri Vainio, Jussi Saukkonen, Charlotte Witmer et al.
      Pages 81-82
    3. John B. Schenkman, Kathy M. Robie, Ingela Jansson
      Pages 83-95
    4. David J. Jollow, James J. Kocsis, Robert Snyder, Harri Vainio, Jussi Saukkonen, Charlotte Witmer et al.
      Pages 96-97
    5. Harry V. Gelboin, James Selkirk, Takao Okuda, Nobuo Nemoto, Shen K. Yang, Friedrich J. Wiebel et al.
      Pages 98-123
    6. David J. Jollow, James J. Kocsis, Robert Snyder, Harri Vainio, Jussi Saukkonen, Charlotte Witmer et al.
      Pages 124-124
    7. David J. Jollow, James J. Kocsis, Robert Snyder, Harri Vainio, Jussi Saukkonen, Charlotte Witmer et al.
      Pages 146-147
    8. David J. Jollow, James J. Kocsis, Robert Snyder, Harri Vainio, Jussi Saukkonen, Charlotte Witmer et al.
      Pages 160-161
    9. E. Dybing, J. R. Mitchell, S. D. Nelson, J. R. Gillette
      Pages 167-172
    10. Ryuichi Kato, Hideyo Noguchi, Masahiko Sugiura, Kazuhide Iwasaki
      Pages 173-177
  4. Inactivation of Reactive Intermediates

    1. Front Matter
      Pages 179-179
    2. Donald M. Jerina, John R. Bend
      Pages 207-236
    3. David J. Jollow, James J. Kocsis, Robert Snyder, Harri Vainio, Jussi Saukkonen, Charlotte Witmer et al.
      Pages 237-238
    4. David J. Jollow, James J. Kocsis, Robert Snyder, Harri Vainio, Jussi Saukkonen, Charlotte Witmer et al.
      Pages 250-250
    5. Harri Vainio, Jukka Marniemi, Max Parkki, Reijo Luoma
      Pages 251-262
    6. David J. Jollow, James J. Kocsis, Robert Snyder, Harri Vainio, Jussi Saukkonen, Charlotte Witmer et al.
      Pages 263-263
  5. Specific Reactive Intermediates

    1. Front Matter
      Pages 269-269
    2. Jerry R. Mitchell, Sidney D. Nelson, Wayne R. Snodgrass, John A. Timbrell
      Pages 271-277
    3. David J. Jollow, James J. Kocsis, Robert Snyder, Harri Vainio, Jussi Saukkonen, Charlotte Witmer et al.
      Pages 278-278
    4. William Lijinsky
      Pages 279-283
    5. David J. Jollow, James J. Kocsis, Robert Snyder, Harri Vainio, Jussi Saukkonen, Charlotte Witmer et al.
      Pages 284-285
    6. R. Snyder, L. S. Andrews, E. W. Lee, C. M. Witmer, M. Reilly, J. J. Kocsis
      Pages 286-301
    7. David J. Jollow, James J. Kocsis, Robert Snyder, Harri Vainio, Jussi Saukkonen, Charlotte Witmer et al.
      Pages 312-313
    8. Robert A. Neal, Tetsuya Kamataki, Marie Lin, Kay A. Ptashne, Ramesh R. Dalvi, Raymond E. Poore
      Pages 320-332
    9. David J. Jollow, James J. Kocsis, Robert Snyder, Harri Vainio, Jussi Saukkonen, Charlotte Witmer et al.
      Pages 333-334
    10. A. H. Conney, A. W. Wood, W. Levin, A. Y. H. Lu, R. L. Chang, P. G. Wislocki et al.
      Pages 335-356
    11. David J. Jollow, James J. Kocsis, Robert Snyder, Harri Vainio, Jussi Saukkonen, Charlotte Witmer et al.
      Pages 357-357
    12. Donald M. Jerina, Haruhiko Yagi, Oscar Hernandez
      Pages 371-378
    13. David J. Jollow, James J. Kocsis, Robert Snyder, Harri Vainio, Jussi Saukkonen, Charlotte Witmer et al.
      Pages 379-379
    14. Tilman Fischbach, Werner Lenk, Dieter Sackerer
      Pages 380-386
    15. A. Malnoë, M. Strolin Benedetti, R. L. Smith, A. Frigerio
      Pages 387-393
    16. Lauri Kangas, Jussi Kanto, Raija Sellman, Aimo Pekkarinen
      Pages 394-397
  6. Reactive Intermediates in Lipid Peroxidation

    1. Front Matter
      Pages 399-399

About this book

Introduction

The concept that detoxication is the inevitable result of biotransformation of xenobiotic compounds by mammalian systems has undergone modification since it was first described. Indeed, despite the fact that R. T. Williams popularized the notion, he was among the first to caution that it was not possible to predict the biological activities of the resulting metabolites. It has become increasingly apparent in recent years that not only do many metabolites of drugs and other chemicals display biological activity but also in many instances these metabolites play an important role in initiating several forms of cancer and are the cause of a variety of types of toxicity. Thus it seems appropriate to collect in one volume a series of reports outlining advances in the study of the formation of chemically active intermediary metabolic products of chemicals, mechanisms of toxicity or carcinogenesis, and pathways for true detoxication of these chemicals. The work of R. T. Williams, beginning in the late 1920s and early 1930s, marked the first concerted effort to understand the biotransformation of foreign chemicals in animals. He investigated the metabolic pathway of numerous compounds in a wide variety of animal species while training large numbers of our colleagues who have been responsible for further advances in biochemistry, pharmacology, and toxicology. Another pioneer in the study of drug metabo­ lism, B. B.

Keywords

Activation DNA Lipid Nucleotide Oxidation animals biochemistry chemistry enzymes metabolism oncogene pharmacology synthesis toxicity toxicology

Editors and affiliations

  • David J. Jollow
    • 1
  • James J. Kocsis
    • 2
  • Robert Snyder
    • 2
  • Harri Vainio
    • 3
  • Jussi Saukkonen
    • 2
  • Charlotte Witmer
    • 2
  • Thomas Walle
    • 1
  1. 1.Medical University of South CarolinaCharlestonUSA
  2. 2.Thomas Jefferson UniversityPhiladelphiaUSA
  3. 3.Institute of Occupational HealthHelsinkiFinland

Bibliographic information