Biological Reactive Intermediates

Formation, Toxicity, and Inactivation

  • David J. Jollow
  • James J. Kocsis
  • Robert Snyder
  • Harri Vainio
  • Jussi Saukkonen
  • Charlotte Witmer
  • Thomas Walle

Table of contents

  1. Front Matter
    Pages i-xi
  2. Reactive Intermediates in Toxicology and Carcinogenesis: Role of Covalent Binding

    1. Front Matter
      Pages 1-1
    2. David J. Jollow, James J. Kocsis, Robert Snyder, Harri Vainio, Jussi Saukkonen, Charlotte Witmer et al.
      Pages 60-61
  3. Formation of Reactive Intermediates

    1. Front Matter
      Pages 63-63
    2. David J. Jollow, James J. Kocsis, Robert Snyder, Harri Vainio, Jussi Saukkonen, Charlotte Witmer et al.
      Pages 81-82
    3. John B. Schenkman, Kathy M. Robie, Ingela Jansson
      Pages 83-95
    4. David J. Jollow, James J. Kocsis, Robert Snyder, Harri Vainio, Jussi Saukkonen, Charlotte Witmer et al.
      Pages 96-97
    5. Harry V. Gelboin, James Selkirk, Takao Okuda, Nobuo Nemoto, Shen K. Yang, Friedrich J. Wiebel et al.
      Pages 98-123
    6. David J. Jollow, James J. Kocsis, Robert Snyder, Harri Vainio, Jussi Saukkonen, Charlotte Witmer et al.
      Pages 124-124
    7. David J. Jollow, James J. Kocsis, Robert Snyder, Harri Vainio, Jussi Saukkonen, Charlotte Witmer et al.
      Pages 146-147
    8. David J. Jollow, James J. Kocsis, Robert Snyder, Harri Vainio, Jussi Saukkonen, Charlotte Witmer et al.
      Pages 160-161
    9. E. Dybing, J. R. Mitchell, S. D. Nelson, J. R. Gillette
      Pages 167-172

About this book

Introduction

The concept that detoxication is the inevitable result of biotransformation of xenobiotic compounds by mammalian systems has undergone modification since it was first described. Indeed, despite the fact that R. T. Williams popularized the notion, he was among the first to caution that it was not possible to predict the biological activities of the resulting metabolites. It has become increasingly apparent in recent years that not only do many metabolites of drugs and other chemicals display biological activity but also in many instances these metabolites play an important role in initiating several forms of cancer and are the cause of a variety of types of toxicity. Thus it seems appropriate to collect in one volume a series of reports outlining advances in the study of the formation of chemically active intermediary metabolic products of chemicals, mechanisms of toxicity or carcinogenesis, and pathways for true detoxication of these chemicals. The work of R. T. Williams, beginning in the late 1920s and early 1930s, marked the first concerted effort to understand the biotransformation of foreign chemicals in animals. He investigated the metabolic pathway of numerous compounds in a wide variety of animal species while training large numbers of our colleagues who have been responsible for further advances in biochemistry, pharmacology, and toxicology. Another pioneer in the study of drug metabo­ lism, B. B.

Keywords

Activation DNA Lipid Nucleotide Oxidation animals biochemistry chemistry enzymes metabolism oncogene pharmacology synthesis toxicity toxicology

Editors and affiliations

  • David J. Jollow
    • 1
  • James J. Kocsis
    • 2
  • Robert Snyder
    • 2
  • Harri Vainio
    • 3
  • Jussi Saukkonen
    • 2
  • Charlotte Witmer
    • 2
  • Thomas Walle
    • 1
  1. 1.Medical University of South CarolinaCharlestonUSA
  2. 2.Thomas Jefferson UniversityPhiladelphiaUSA
  3. 3.Institute of Occupational HealthHelsinkiFinland

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4613-4124-6
  • Copyright Information Springer-Verlag US 1977
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-4126-0
  • Online ISBN 978-1-4613-4124-6
  • About this book