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Handbook of Psychopharmacology

Volume 14 Affective Disorders: Drug Actions in Animals and Man

  • Leslie L. Iversen
  • Susan D. Iversen
  • Solomon H. Snyder

Table of contents

  1. Front Matter
    Pages i-xv
  2. David J. Kupfer, Thomas P. Detre
    Pages 199-232
  3. Nelson Howard Hendler
    Pages 233-273
  4. Baron Shopsin, Samuel Gershon
    Pages 275-325
  5. Back Matter
    Pages 371-379

About this book

Introduction

Underlying the design of the Handbook of Psychopharmacology is a prejudice that the study of drug influences on the mind has advanced to a stage where basic research and clinical application truly mesh. These later volumes of the Handbook are structured according to this conception. In certain volumes, groups of drugs are treated as classes with chapters ranging from basic chemistry to clinical application. Other volumes are assembled around topic areas such as anxiety or affective disorders. Thus, besides chapters on individual drug classes, we have included essays addressing broad areas such as "The Limbic-Hypothalamic-Pituitary-Adrenal System and Human Be­ havior" and "Peptides and the Central Nervous System. " Surveying these diverse contributions, one comes away with a sentiment that, far from being an "applied" science borrowing from fundamental brain chemistry and physiology, psychopharmacology has instead provided basic researchers with the tools and conceptual approaches which now are advancing neurobiology to a central role in modern biology. Especially gratifying is the sense that, while contributing to an understanding of how the brain functions, psychopharmacology is a discipline whose fruits offer genuine help to the mentally ill with promises of escalating benefits in the future. L. L. 1. S. D. 1. S. H. S. VB CONTENTS CHAPTER 1 Monoamine Oxidase Inhibitors: Animal Pharmacology RICHARD F. SQUIRES 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1. 1. Localization. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1. 2. Function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 1. 3. Mechanisms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. Inhibition of 5-HT and Catecholamine Synthesis. . . . . . . . 5 3. Inhibition of Spontaneous Firing of 5-HT Neurons. . . . . .

Keywords

brain chemistry drug physiology psychopharmacology research

Editors and affiliations

  • Leslie L. Iversen
    • 1
  • Susan D. Iversen
    • 2
  • Solomon H. Snyder
    • 3
  1. 1.Department of PharmacologyUniversity of CambridgeUK
  2. 2.Department of PsychologyUniversity of CambridgeUK
  3. 3.Departments of Pharmacology and PsychiatryThe Johns Hopkins University School of MedicineUSA

Bibliographic information