The Immunopathology of Lymphoreticular Neoplasms

  • J. J. Twomey
  • Robert A. Good

Part of the Comprehensive Immunology book series (COMIMUN, volume 4)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Max D. Cooper, Alexander R. Lawton
    Pages 1-21
  3. Richard K. Gershon, Charles M. Metzler
    Pages 23-51
  4. E. J. Yunis, G. Fernandes, Robert A. Good
    Pages 53-80
  5. Raymond D. A. Peterson
    Pages 81-127
  6. Nicholas J. Vianna
    Pages 181-201
  7. Beatrice D. Spector, Guy S. Perry III, Robert A. Good, John H. Kersey
    Pages 203-222
  8. Israel Penn
    Pages 223-237
  9. Robert J. Lukes, John W. Parker
    Pages 239-279
  10. Frederick P. Siegal
    Pages 281-323
  11. Edward C. Franklin, Joel Buxbaum
    Pages 361-390
  12. Dennis H. Wright
    Pages 391-424
  13. Maxime Seligmann, Jean-Claude Rambaud
    Pages 425-447
  14. Richard H. Marshak, Arthur E. Lindner, Daniel Maklansky
    Pages 449-491
  15. John H. Kersey, Mark E. Nesbit
    Pages 533-542

About this book

Introduction

Until recently, understanding of the lymphomas was limited and largely descriptive. Attention has been focused, for the most part, upon morphological issues and clinical matters. Although useful, this approach has many shortcomings. The true cytoidentity of primary neoplastic cells was not established by these methods, nor could their clonal nature be recognized. The more overt changes in immunological function, such as monoclonal gammopathies and immunodeficiencies, were appre­ ciated as important components of these diseases. However, subtle immunological perturbations were not recognized. Furthermore, associations were not established between the lymphoreticular neoplasms on the one hand and both primary and secondary immunological abnormalities on the other. There has been considerable recent progress in the fields of immunobiology, cytology, and immunochemistry. These new approaches have proved readily applicable to studies on the lymphomas. The term "lymphoma" has been applied to a heterogeneous group of neo­ plasms that involve lymphoid tissues. This term is not altogether satisfactory, since it implies that cells of primarily the lymphoid series are involved in the neoplastic process. Some neoplasms, heretofore classified as "lymphomas," now appear, from the results of penetrating analysis using newer methodology, to be malignan­ cies of the macrophage series, rather than of the lymphocytic series. These neo­ plasms include Hodgkin's disease and a minority of neoplasms previously referred to as "histiocytic" lymphomas. The majority of these "histiocytic" lymphomas are now known to be lymphoid malignancies involving the B-cell series.

Keywords

diseases immunobiology pathology

Editors and affiliations

  • J. J. Twomey
    • 1
  • Robert A. Good
    • 2
  1. 1.Veterans Administration HospitalHoustonUSA
  2. 2.Sloan-Kettering Institute for Cancer ResearchNew YorkUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4613-4015-7
  • Copyright Information Springer-Verlag US 1978
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-4017-1
  • Online ISBN 978-1-4613-4015-7
  • About this book