Cellular and Molecular Biology of Neuronal Development

1. Front Matter

   Pages i-xxv

   PDF

2. Embryogenesis and Morphogenesis of the Nervous System: Session Chairman: James A. Weston

   1. Front Matter

      Pages 1-1

      PDF

   2. A Model for Cell-Line Divergence in the Ontogeny of the Peripheral Nervous System

      • Nicole M. Le Douarin

      Pages 3-28

   3. Emergence of Neuronal and Glial Cell Lineages in Primate Brain

      • Pasko Rakic

      Pages 29-50

   4. Heterogeneity in Neural Crest Cell Populations

      • James A. Weston, John Girdlestone, Gary Ciment

      Pages 51-62

   5. The First Growth Cones in the Central Nervous System of the Grasshopper Embryo

      • Michael J. Bastiani, Corey S. Goodman

      Pages 63-84

3. Developmental Expression of Neuronal Phenotypic Characters: Session Chairman: Ira B. Black

   1. Front Matter

      Pages 85-85

      PDF

   2. Surface-Bound and Released Neuronal Glycoconjugates

      • Paul H. Patterson

      Pages 87-94

   3. The Differentiation of Membrane Properties of Spinal Neurons

      • Nicholas C. Spitzer

      Pages 95-106

   4. The Accumulation of Acetylcholine Receptors at Nerve—Muscle Synapses in Culture

      • Gerald D. Fischbach, Lorna W. Role, Richard I. Hume

      Pages 107-115

   5. Transmitter Phenotypic Plasticity In Developing and Mature Neurons in Vivo

      • Ira B. Black, Joshua E. Adler, Martha C. Bohn, G. Miller Jonakait, John A. Kessler, Keith A. Markey

      Pages 117-130

4. Nerve Growth Factor as a Model Growth Factor: Session Chairman: Eric M. Shooter

   1. Front Matter

      Pages 131-131

      PDF

   2. Mechanisms of the Promotion of Neurite Outgrowth by Nerve Growth Factor

      • Lloyd A. Greene, David E. Burstein, James L. Connolly, Steven H. Green, P. John Seeley, Michael L. Shelanski

      Pages 133-141

   3. Cultured Sympathetic Neurons in the Study of Nerve Growth Factor Action

      • Edward Hawrot

      Pages 143-163

   4. Guanethidine-Induced Destruction of Sympathetic Neurons: An Autoimmune “Disease” Prevented by Nerve Growth Factor

      • Eugene M. Johnson Jr., Pamela Toy Manning

      Pages 165-176

   5. Enhanced Dependence of Fetal Mouse Neurons on Trophic Factors after Taxol Exposure in Organotypic Cultures

      • Stanley M. Crain, Edith R. Peterson

      Pages 177-200

   6. The Interaction of Nerve Growth Factor with Its Specific Receptors

      • Arne Sutter, Markus Hosang, Ronald D. Vale, Eric M. Shooter

      Pages 201-214

5. New Neuronal Growth Factors: Session Chairman: Hans Thoenen

   1. Front Matter

      Pages 215-215

      PDF

   2. Multiple Sites for the Regulation of Neurite Outgrowth

      • Frank Collins

      Pages 217-230

   3. Nerve Growth Factors in Chick and Rat Tissues

      • Ted Ebendal, Lars Olson, Åke Seiger, Makonnen Belew

      Pages 231-242

A central problem in neurobiology concerns mechanisms that generate the pro­ found diversity and specificity of the nervous system. What is the substance of diversification and specificity at the molecular, cellular, and systems levels? 4 How, for example, do 1011 neurons each form approximately 10 interconnec­ tions, allowing normal physiological function? How does disruption of these processes result in human disease? These proceedings represent the efforts of molecular biologists, embryologists, neurobiologists, and clinicians to approach these issues. in this volume are grouped by subject to present the varieties The chapters of methods used to approach each individual area. Section I deals with embry­ ogenesis and morphogenesis of the nervous system. In Chapter 3, Weston and co-workers describe the use of monoclonal antibodies that recognize specific neuronal epitopes (including specific gangliosides) for the purpose of defining heterogeneity in the neural crest, an important model system. Immunocyto­ chemical analysis reveals the existence of distinct sUbpopulations within the crest at extremely early stages; cells express neuronal or glial binding patterns at the time of migration. Consequently, interactions with the environment may select for predetermined populations. Le Douarin reaches similar conclusions in Chapter 1 by analyzing migratory pathways and developmental potentials in crest of quail-

• Nervous System
• development
• neurobiology
• neurons
• ontogeny
• phenotype
• phenotypic plasticity
• tissue

• Cornell University Medical College, New York, USA

  Ira B. Black

Policies and ethics