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Cellular and Molecular Biology of Neuronal Development

  • Ira B. Black

Table of contents

  1. Front Matter
    Pages i-xxv
  2. Embryogenesis and Morphogenesis of the Nervous System: Session Chairman: James A. Weston

    1. Front Matter
      Pages 1-1
    2. James A. Weston, John Girdlestone, Gary Ciment
      Pages 51-62
    3. Michael J. Bastiani, Corey S. Goodman
      Pages 63-84
  3. Developmental Expression of Neuronal Phenotypic Characters: Session Chairman: Ira B. Black

    1. Front Matter
      Pages 85-85
    2. Gerald D. Fischbach, Lorna W. Role, Richard I. Hume
      Pages 107-115
    3. Ira B. Black, Joshua E. Adler, Martha C. Bohn, G. Miller Jonakait, John A. Kessler, Keith A. Markey
      Pages 117-130
  4. Nerve Growth Factor as a Model Growth Factor: Session Chairman: Eric M. Shooter

    1. Front Matter
      Pages 131-131
    2. Lloyd A. Greene, David E. Burstein, James L. Connolly, Steven H. Green, P. John Seeley, Michael L. Shelanski
      Pages 133-141
    3. Arne Sutter, Markus Hosang, Ronald D. Vale, Eric M. Shooter
      Pages 201-214
  5. New Neuronal Growth Factors: Session Chairman: Hans Thoenen

    1. Front Matter
      Pages 215-215
    2. Ted Ebendal, Lars Olson, Åke Seiger, Makonnen Belew
      Pages 231-242
    3. Silvio Varon, Marston Manthorpe
      Pages 251-275
  6. Molecular Biology of Neural Development and Function: Session Chairman: Xandra O. Breakefield

    1. Front Matter
      Pages 277-277
    2. Edward Herbert, Michael Comb, Haim Rosen, Gerard Martens
      Pages 279-292
    3. Axel Ullrich, Alane Gray, Cara Berman, Thomas J. Dull
      Pages 293-307
    4. Xandra O. Breakefield, Carmela M. Castiglione, Lisa M. Coussens, Felicia B. Axelrod, Axel Ullrich
      Pages 309-328
  7. Diseases of Development: Session Chairman: Ira B. Black

  8. Back Matter
    Pages 355-363

About this book

Introduction

A central problem in neurobiology concerns mechanisms that generate the pro­ found diversity and specificity of the nervous system. What is the substance of diversification and specificity at the molecular, cellular, and systems levels? 4 How, for example, do 1011 neurons each form approximately 10 interconnec­ tions, allowing normal physiological function? How does disruption of these processes result in human disease? These proceedings represent the efforts of molecular biologists, embryologists, neurobiologists, and clinicians to approach these issues. in this volume are grouped by subject to present the varieties The chapters of methods used to approach each individual area. Section I deals with embry­ ogenesis and morphogenesis of the nervous system. In Chapter 3, Weston and co-workers describe the use of monoclonal antibodies that recognize specific neuronal epitopes (including specific gangliosides) for the purpose of defining heterogeneity in the neural crest, an important model system. Immunocyto­ chemical analysis reveals the existence of distinct sUbpopulations within the crest at extremely early stages; cells express neuronal or glial binding patterns at the time of migration. Consequently, interactions with the environment may select for predetermined populations. Le Douarin reaches similar conclusions in Chapter 1 by analyzing migratory pathways and developmental potentials in crest of quail-

Keywords

Nervous System development neurobiology neurons ontogeny phenotype phenotypic plasticity tissue

Editors and affiliations

  • Ira B. Black
    • 1
  1. 1.Cornell University Medical CollegeNew YorkUSA

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