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Cardiac Arrhythmias: New Therapeutic Drugs and Devices

Proceedings of the Symposium on New Drugs and Devices, held at Philadelphia, PA October 4 and 5, 1984

  • Conference proceedings
  • © 1985

Overview

Editors:
  1. Joel Morganroth

    1. Likoff Cardiovascular Institute of Hahnemann Medical College and Hospital, USA

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  2. E. Neil Moore

    1. School of Veterinary Medicine, University of Pennsylvania, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 47)

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Table of contents (22 papers)

  1. Front Matter

    Pages i-xii
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  2. Basic considerations

    1. Front Matter

      Pages 1-1
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    2. What Animal Models are Useful in Selecting New Antiarrhythmic Drugs?

      • E. Neil Moore, Joseph F. Spear
      Pages 3-11

    3. How to Test for Antiarrhythmic Drugs

      • Brian F. Hoffman
      Pages 12-21

    4. Initial Evaluation of New Antiarrhythmic Agents in Man: Normal Volunteers or Patients?

      • Raymond L. Woosley, John A. Oates
      Pages 22-35

    5. Is There a Rational Basis for the Modified Classification of Antiarrhythmic Drugs?

      • Donald C. Harrison
      Pages 36-40

  3. Back Matter

    Pages 41-47
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  5. Back Matter

    Pages 167-177
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Keywords

About this book

In summary, there are many animal models that are useful in selecting new antiarrhythmic drugs. The selection of which model is most idea depends upon precisely what question is being asked. The large number of experimental models used to evaluate antiarrhythmic compounds points out the inability of anyone model to define the probability of antiarrhythmic efficacy in man. It has therefore become standard practice to utilize a batter of animal models for the evaluation of new antiarrhythmic agents. Each model has its own advantages and disadvantages and it is necessary to understand each model fully in oder to evaluate experimental findings and apply them to clinical settings. We believe that the availability of the chronic myocardial infarction ventricular tachyarrhythmia model provides 1) an excellent opportunity to more precisely understand arrhythmia mechanisms, 2) to develop new techniques such as signal averaging for evaluating late low level potentials identifying hearts at high risk of sudden death 3) to identify new antifibrillatory drugs versus drugs that are effective primarily against PVC's and ventricular tachycardia 4) to identify new surgical techniques to eliminate VT/VF, and 5) to evaluate new pacing modalities including implantable cardioverters. Although all animal models are wrong, many are very useful in furthering our knowledge directed at decreasing the distressingly high mortality from heart disease. NORMAL HtART TACHYCMDIA HtART , .. '" \ I I I I I I I I I .

Editors and Affiliations

  • Likoff Cardiovascular Institute of Hahnemann Medical College and Hospital, USA

    Joel Morganroth

  • School of Veterinary Medicine, University of Pennsylvania, USA

    E. Neil Moore

Bibliographic Information

  • Book Title: Cardiac Arrhythmias: New Therapeutic Drugs and Devices

  • Book Subtitle: Proceedings of the Symposium on New Drugs and Devices, held at Philadelphia, PA October 4 and 5, 1984

  • Editors: Joel Morganroth, E. Neil Moore

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/978-1-4613-2595-6

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Martinus Nijhoff Publishing, Boston 1985

  • Hardcover ISBN: 978-0-89838-716-2Published: 30 April 1985

  • Softcover ISBN: 978-1-4612-9626-3Published: 02 October 2011

  • eBook ISBN: 978-1-4613-2595-6Published: 06 December 2012

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: XII, 356

  • Topics: Cardiology, Pharmaceutical Sciences/Technology

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