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Antibodies

Structure, Synthesis, Function, and Immunologic Intervention in Disease

  • Andor Szentivanyi
  • Paul H. Maurer
  • Bernard W. Janicki

Table of contents

  1. Front Matter
    Pages i-viii
  2. Structures of Antibodies and the Combining Site

    1. Front Matter
      Pages 1-1
    2. Heinz Kohler, Thomas Kieber-Emmons
      Pages 11-17
    3. Elvin A. Kabat
      Pages 19-40
  3. B Cell Development, Function, Repertoire and Activation

    1. Front Matter
      Pages 41-41
    2. Max D. Cooper
      Pages 43-47
    3. Nicolas Fasel, Michael Briskin, Carla Carter, Herman Govan, Gary Hermanson, Ronald Law et al.
      Pages 49-60
    4. Barbara G. Froscher, Norman R. Klinman
      Pages 61-69
    5. Junichiro Mizuguchi, Michael Beaven, Peter Hornbeck, Wayne Tsang, William E. Paul
      Pages 71-78
  4. Antiboby Idiotypes, Anti-Idiotypes, and Network Regulation

    1. Front Matter
      Pages 79-79
    2. Michael F. Gurish, Tamar Ben-Porat, Alfred Nisonoff
      Pages 81-89
    3. Carol Victor-Kobrin, Zahava Barak, F. A. Bonilla, Constantin Bona
      Pages 91-105
    4. Gregory W. Siskind, Edmond A. Goidl, Young Tai Kim, Marc E. Weksler, G. Jeanette Thorbecke
      Pages 107-115
  5. Immunologic Intervention with Anti-Idiotype Antibodies

    1. Front Matter
      Pages 117-117
    2. B. F. Erlanger, W. L. Cleveland, N. H. Wasserman, H. H. Ku, B. L. Hill, R. Sarangarajan et al.
      Pages 119-134
    3. Norman Talal
      Pages 155-163
  6. Immunologic Intervention with Monoclonal Antibodies

    1. Front Matter
      Pages 165-165
    2. Sherie L. Morrison, Letitia A. Wims, Polly D. Gregor, Barry J. Kobrin, Vernon T. Oi
      Pages 167-178
    3. Jonathan W. Uhr, R. Jerrold Fulton, Ellen S. Vitetta
      Pages 179-187
  7. Overview and Comments

    1. Front Matter
      Pages 201-201
    2. Gregory W. Siskind
      Pages 203-206
  8. Back Matter
    Pages 207-215

About this book

Introduction

This publication is based on a Symposium that has been held in Clearwater, Florida on February 19-21, 1986, on antibodies, their structure, synthesis, function, and clinical applicability in disease. Organization of this symposium by the University of South Florida College of Medicine was prompted by the unparalleled current expansion of information on these topics in general, and in the field of antibody diver­ sity, in particular. The issues that surround the last named dimension of this field, began to surface in the late 1950's with the first conclusive genetic studies having been answered, and a new set of concepts has been de­ fined. As we see it from the material presented in this volume, now new and different questions are being raised and answered by studies in progress, and it may be expected that there will be other questions that will be with us for a considerably longer time. We believe that the symposium brought together many prominent investi­ gators with different backgrounds and training experiences such as immunolo­ gists, microbiologists, biochemists, molecular biologists, and clinical sci­ entists, thus providing an excellent example of the interdisciplinary value of modern immunology and modern biomedical science in general. We believe, therefore, that bringing these complex topics to a wide audience of bio­ medical scientists through this symposium as well as this volume is of value to the scientific and to the medical community.

Keywords

aging antibody autoimmune disease cell diseases gene gene expression immunoglobulin immunology virus

Editors and affiliations

  • Andor Szentivanyi
    • 1
  • Paul H. Maurer
    • 2
  • Bernard W. Janicki
    • 3
  1. 1.Department of Pharmacology and TherapeuticsUnversity of South FloridaTampaUSA
  2. 2.Department of BiochemistryJefferson Medical College of Thomas Jefferson UniversityPhiladelphiaUSA
  3. 3.Immunology, Allergic and Immunologic Diseases Program National Institute of Allergy and Infectious DiseaseNational Institutes of HealthBethesdaUSA

Bibliographic information