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Breast Cancer: Scientific and Clinical Progress

Proceedings of the Biennial Conference for the International Association of Breast Cancer Research, Miami, Florida, USA — March 1–5, 1987

  • Marvin A. Rich
  • Jean C. Hager
  • Diana M. Lopez

Part of the Developments in Oncology book series (DION, volume 56)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Oncogenes/Growth Factors—Their Role in Breast Cancer

  3. Mammary Gland Development, Differentiation and Pathology in Relationship to Malignancy

    1. A. Sonnenberg, J. Daams, F. Delemarre, P. Lens, J. Hilgers
      Pages 88-111
    2. S. Gendler, J. Burchell, A. Girling, R. Millis, T. Duhig, J. Taylor-Papadimitriou
      Pages 112-126
    3. S. L. Schor, A. M. Schor, A. Howell, J. Haggie
      Pages 142-157
    4. G. Bussolati, M. Papotti, A. Sapino, P. Gugliotta, L. Macri’
      Pages 158-173
    5. N. I. Smorodinsky, I. Tsarfaty, Y. Ghendler, R. Lupu, I. Keydar, S. Argov et al.
      Pages 174-184
    6. Diana M. Lopez, Ranga R. Padmanabhan, Lourdes M. Rivera, Ronald D. Paul, Lynn Herbert, Carolyn Cray et al.
      Pages 185-205
    7. Adeline J. Hackett, Helene S. Smith, Robert Stern
      Pages 206-212
  4. New Developments in Clinical Applications

    1. D. W. Kufe, D. Hayes, M. Abe, T. Ohno
      Pages 262-273
    2. A. Fallenius, G. Auer
      Pages 274-284
    3. A. Schauer, H. Rothe, I. Balzer, M. Bergholz, R. Brehler, I. Fiebig et al.
      Pages 299-320
    4. Paul A. Kelly, Henri Rochefort
      Pages 321-327
  5. New Perspectives in the Prevention and Control of Breast Cancer

    1. E. L. Wynder, L. Cohen, D. Rose
      Pages 328-336
    2. Jean C. Hager, Philip Furmanski, Marvin A. Rich
      Pages 356-374
  6. Back Matter
    Pages 375-389

About this book

Introduction

Effective control of breast cancer depends on three types of research accomplishment -- understanding the disease's origins and progression: successfully applying this knowledge to methods of detection, diagnosis and treatment: and finding ways to make these advances truly available to the public as effectively as possible. The significant progress that is occurring across this entire spectrum of pioneering investigation is reflected in these proceedings of the 1987 biennial conference of the International Association for Breast Cancer Research. The first section of the book focuses on oncogenes and chemical effectors that may play key roles in early cell transformation leading to breast cancer. Research discussed includes identification of specific oncogenes which appear to be involved in the disease, study of their activation and expression, examination of the biological effects of various growth factors isolated from breast cancer cell lines, and investigation of the molecular mechanisms by which estrogens promote and stimulate growth of breast cancers. The second group of chapters deals with several other complex factors and phenomena which may influence tumor formation in the breast, for example, expression of abnormalities by fibroblasts, disruption of epithelial-mesenchymal interactions, and loss of ability nili to synthesize normal basal lamina resulting in alterations in the extracellular matrix. Clarification of the processes of normal mammary gland development and differentiation is central to much of this work.

Keywords

DNA cancer prevention carcinogenesis carcinoma cell hormones oncogene pathogenesis pathology prevention screening tumor

Editors and affiliations

  • Marvin A. Rich
    • 1
  • Jean C. Hager
    • 1
  • Diana M. Lopez
  1. 1.AMC Cancer Research CenterDenverUSA

Bibliographic information