Prediction of Protein Structure and the Principles of Protein Conformation

  • Gerald D. Fasman

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Jane S. Richardson, David C. Richardson
    Pages 1-98
  3. Gerald Stubbs
    Pages 117-148
  4. J. Andrew McCammon, Chung F. Wong, Terry P. Lybrand
    Pages 149-159
  5. D. H. J. Mackay, A. J. Cross, A. T. Hagler
    Pages 317-358
  6. Peter Prevelige Jr., Gerald D. Fasman
    Pages 391-416
  7. Russell F. Doolittle
    Pages 599-623
  8. George D. Rose, Jonathan E. Dworkin
    Pages 625-633
  9. David Eisenberg, Morgan Wesson, William Wilcox
    Pages 635-646
  10. Fred E. Cohen, Irwin D. Kuntz
    Pages 647-705
  11. Fritz Jähnig
    Pages 707-717

About this book

Introduction

The prediction of the conformation of proteins has developed from an intellectual exercise into a serious practical endeavor that has great promise to yield new stable enzymes, products of pharmacological significance, and catalysts of great potential. With the application of predic­ tion gaining momentum in various fields, such as enzymology and immunology, it was deemed time that a volume be published to make available a thorough evaluation of present methods, for researchers in this field to expound fully the virtues of various algorithms, to open the field to a wider audience, and to offer the scientific public an opportunity to examine carefully its successes and failures. In this manner the practitioners of the art could better evaluate the tools and the output so that their expectations and applications could be more realistic. The editor has assembled chapters by many of the main contributors to this area and simultaneously placed their programs at three national resources so that they are readily available to those who wish to apply them to their personal interests. These algorithms, written by their originators, when utilized on pes or larger computers, can instantaneously take a primary amino acid sequence and produce a two-or three-dimensional artistic image that gives satisfaction to one's esthetic sensibilities and food for thought concerning the structure and function of proteins. It is in this spirit that this volume was envisaged.

Keywords

Amino acid Peptide development enzymes protein protein folding proteins

Editors and affiliations

  • Gerald D. Fasman
    • 1
  1. 1.Graduate Department of BiochemistryBrandeis UniversityWalthamUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4613-1571-1
  • Copyright Information Springer-Verlag US 1989
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-8860-2
  • Online ISBN 978-1-4613-1571-1
  • About this book