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Pharmacological Approaches to the Treatment of Brain and Spinal Cord Injury

  • Donald G. Stein
  • Bernhard A. Sabel

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Michael S. Beattie, Bradford T. Stokes, Jacqueline C. Bresnahan
    Pages 43-74
  3. Tracy K. McIntosh, Alan I. Faden
    Pages 89-102
  4. Franz Hefti, William J. Weiner
    Pages 103-119
  5. Dennis M. Feeney, Richard L. Sutton
    Pages 121-142
  6. R. Dal Toso, G. Ferrari, G. Vantini, G. Toffano, A. Leon, S. D. Skaper
    Pages 143-165
  7. Gary L. Dunbar, Donald G. Stein
    Pages 195-218
  8. Stephen E. Karpiak, Yu S. Li, Sahebarao P. Mahadik
    Pages 219-231
  9. Paul De Koning, Willem Hendrik Gispen
    Pages 233-258
  10. Gustave Moonen, Paul Delree, Pierre Leprince, Jean-Michel Rigo, Bernard Rogister, Philippe P. Lefebvre
    Pages 259-280
  11. Michal Schwartz, Adrian Harel, Cathy Stein-Izsak, Vered Lavie, Yosef Bawnik, Arie Solomon et al.
    Pages 281-300
  12. Manuel Nieto-Sampedro
    Pages 301-337
  13. Bruno Will, Viviane Pallage, Guy Toniolo, Franz Hefti
    Pages 339-360
  14. Andrew Kertesz
    Pages 361-376
  15. Back Matter
    Pages 377-385

About this book

Introduction

Although there are over 400,000 people each year in the United States alone who suffer from traumatic injury to the central nervous system (CNS), no phar­ macological treatment is currently available. Considering the enormity of the problem in terms of human tragedy as well as the economic burden to families and societies alike, it is surprising that so little effort is being made to develop treatments for these disorders. Although no one can become inured to the victims of brain or spinal cord injuries, one reason that insufficient time and effort have been devoted to research on recovery is that it is a generally held medical belief that nervous system injuries are simply not amenable to treatment. At best, current therapies are aimed at providing symptomatic relief or focus on re­ habilitative measures and the teaching of alternative behavioral strategies to help patients cope with their impairments, with only marginal results in many cases. Only within the last decade have neuroscientists begun to make serious inroads into understanding and examining the inherent "plasticity" found in the adult CNS. Ten years or so ago, very few researchers or clinicians would have thought that damaged central neurons could sprout new terminals or that intact nerve fibers in a damaged pathway could proliferate to replace inputs from neurons that died as a result of injury.

Keywords

CNS brain brain injury catecholamines dopamine forebrain nervous system neurobiology neurons opioid physiology rehabilitation research spinal cord trauma

Editors and affiliations

  • Donald G. Stein
    • 1
  • Bernhard A. Sabel
    • 2
  1. 1.Clark UniversityWorcesterUSA
  2. 2.University of MunichMunichFederal Republic of Germany

Bibliographic information