Progress in Parkinson Research

1. Trophic Effects of Striatal Proteins on Central Dopaminergic Neurons in Culture

   • Humberto B. Valdes, Doris Nonner, Dino Rulli, Leonard Gralnik, John Barrett

   Pages 163-171

2. Age-Related Changes of Dopaminergic Functions

   • Caleb E. Finch

   Pages 173-179

3. Adrenal Medulla Transplants in Rodents and Nonhuman Primates: Regenerative Responses in the Host Brain

   • Don Marshall Gash, Massimo S. Fiandaca, Jeffrey H. Kordower, John T. Hansen

   Pages 181-186

4. Preliminary Evaluation and Report on Human Adrenal Medullary Grafting

   • Roy A. E. Bakay

   Pages 187-191

5. Behaviorial Performance Improves After Fetal Substantia Nigra Transplant in Bonnet Monkeys with MPTP Induced Parkinsonism

   • C. R. Freed, J. B. Richards, M. L. Reite

   Pages 193-196

6. Mechanisms of Action of Substantia Nigra and Adrenal Medulla Grafts

   • William J. Freed, Jill B. Becker

   Pages 197-204

7. Recent Advances In Dopaminergic Implants

   • I. J. Kopin, K. S. Bankiewicz, R. J. Plunkett, L. Porrino, D. M. Jacobowitz, W. T. London et al.

   Pages 205-210

8. Reversal of Experimental Parkinsonism in African Green Monkeys Following Fetal Dopamine Neuron Transplantation

   • T. J. Collier, D. E. Redmond Jr., R. H. Roth, J. D. Elsworth, J. R. Sladek Jr.

   Pages 211-218

9. Transplantation of Human Dopaminergic Neurons in Parkinsonism: Experimental Reality and Future Clinical Feasibility

   • Ake Seiger, Lars Olson, Ingrid Stromberg, Marc Bygdeman, Menek Goldstein, Barry Hoffer

   Pages 219-223

10. Back Matter

    Pages 225-228

    PDF

In the past five years significant progress has been made in our basic and clinical under­ standing of Parkinson's disease. The discovery that MPTP, a relatively simple molecule, is able to induce parkinsonism in otherwise healthy adult humans, and the recent interest in the possibility of "transplantation" procedures as a therapeutic modality in the treatment of Parkin­ son's disease have generated enormous interest in research related to Parkinson's disease. In this setting, the National Parkinson Foundation decided to organize a research meeting to bring together scientists actively engaged in research relevant to the study of Parkinson's disease, to accelerate its progress and to promote an exchange of ideas. This meeting took place in Janu­ ary 1988 at Key Biscayne, Florida. It was decided to publish the proceedings ofthis meeting to allow rapid documentation of the participants current findings and views regarding this rapidly of this volume follows the organization of the meeting and begins evolving field. The structure with a clinical and neuropathological review of current knowledge regarding Parkinson's dis­ ease. Since dopaminergic neurons playa major role in the pathophysiology of the disease, many of the contributions relate to some aspects of dopaminergic function including localiza­ tion, regulation, and pharmacology of dopamine receptors. A special effort has been made to provide a summary of the present knowledge of the cellular biology of the dopaminergic neurons.

• Parkinson
• behavior
• biochemistry
• biology
• brain
• cell
• cell culture
• environment
• neurons
• neuropathology
• pathology
• pharmacology
• physiology
• protein
• tissue

• National Parkinson Foundation, Miami, USA

  Franz Hefti, William J. Weiner

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