Eicosanoids, Apolipoproteins, Lipoprotein Particles, and Atherosclerosis

  • Claude L. Malmendier
  • Petar Alaupovic

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 243)

Table of contents

  1. Front Matter
    Pages i-x
  2. Eicosanoids

    1. Salvador Moncada
      Pages 1-11
    2. J. M. Boeynaems, D. Demolle, S. Pirotton, E. Raspe, M. Lecomte, A. Hepburn et al.
      Pages 13-20
    3. R. J. Gryglewski, E. Kostka-Trabka, A. Dembinska-Kiec, R. Korbut
      Pages 21-29
    4. Aaron J. Marcus, Lenore B. Safier, Harris L. Ullman, Naziba Islam, M. Johan Broekman, J. R. Falck et al.
      Pages 31-36
    5. David P. Hajjar, Aaron J. Marcus, Kenneth B. Pomerantz, Katherine A. Hajjar
      Pages 37-45
    6. Andreas J. R. Habenicht, Peter Salbach, Matthias Goerig
      Pages 55-59
  3. Genetics of Apolipoproteins

    1. J. M. Ordovas, D. C. King, E. J. Schaefer
      Pages 61-65
    2. Marie-France Dumon, Monique Clerc, Michel Clerc
      Pages 67-73
    3. R. E. Ferrell, M. I. Kamboh, B. S. Sepehrnia, L. L. Adams-Campbell, K. M. Weiss
      Pages 81-85
    4. Louis M. Havekes, Peter de Knijff, Marijke Smit, Rune R. Frants
      Pages 87-93
    5. David J. Galton
      Pages 95-105
  4. Structure of Apolipoproteins and Lipoproteins

    1. Vassilis I. Zannis, M. Mahmood Hussain, Margarita Hadzopoulou-Cladaras, Anastasia Kouvatsi, Dimitris Kardassis, Christos Cladaras
      Pages 107-121
    2. Mary T. Walsh, James A. Hamilton, David Atkinson, Donald M. Small
      Pages 123-132
    3. J-L De Coen, C. Delcroix, J-F. Lontie, C. L. Malmendier
      Pages 133-137
    4. M. Ayrault-Jarrier, E. Bekaert, E. Petit, D. Pastier, J. Polonovski, B. Pau et al.
      Pages 149-155

About this book

Introduction

Plasma lipoproteins constitute a unique macromolecular system of lipid-protein complexes responsible for the transport of lipids from their sites of origin to their sites of utilization either as metabolic fuel or as structural components of cell membranes. Although studies on the role of lipoproteins in the mechanism of lipid transport are meritorious in their own right, the ever-increasing interest in chemical and functional properties of this remarkable class of conjugated proteins stems from the impressive evidence of their direct involvement in the genesis and develop­ ment of atherosclerotic lesions. The initial emphasis on neutral lipids and phospholipids as the most characteristic constituents of operationally­ defined lipoprotein classes has shifted in recent years to their protein moieties or apolipoproteins. The discovery of a number of apolipoproteins and characterization of familial hypolipoproteinemias as apolipoprotein deficiency disorders indicated that apolipoproteins play an essential role in maintaining the structural stability and integrity of lipoprotein particles. In addition to their role in the formation of lipoproteins, apolipoproteins were shown to perform a variety of functions in metabolic conversion of lipoproteins and their interactions with cellular surfaces. Results from several laboratories have demonstrated that the chemical and metabolic heterogeneity of operationally-defined lipoprotein classes is due to the presence of several discrete lipoprotein particles with similar physical properties but different and characteristic apolipoprotein composition. Thus, the apolipoproteins have emerged not only as essential structural and functional constituents of lipoproteins but also as unique chemical markers for identifying and classifying lipoprotein particles.

Keywords

Lipoprotein atherosclerosis cytokine genetics heart high-density lipoprotein (HDL) protein protein complexes tertiary structure

Editors and affiliations

  • Claude L. Malmendier
    • 1
    • 2
  • Petar Alaupovic
    • 3
  1. 1.Research Foundation on AtherosclerosisBrusselsBelgium
  2. 2.The Free University of BrusselsBrusselsBelgium
  3. 3.Lipoprotein and Atherosclerosis Research ProgramOklahoma Medical Research FoundationOklahoma CityUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4613-0733-4
  • Copyright Information Springer-Verlag US 1988
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-8055-2
  • Online ISBN 978-1-4613-0733-4
  • Series Print ISSN 0065-2598
  • About this book