Magnetic Resonance in Experimental and Clinical Oncology

1. Front Matter

   Pages i-xv

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2. 31P and 13C NMR Studies of Acute and Chronic Adriamycin Cardiotoxicity

   • John C. Chatham, Jerry D. Glickson

   Pages 1-22

3. Relationship of 31P NMR Measurements to Tumor Biology

   • Paul Okunieff

   Pages 23-57

4. Measurement of Tumor Blood Flow by Deuterium Nuclear Magnetic Resonance Spectroscopy: Application to Murine RIF-1 Tumor

   • Seong-gi Kim, Yuying C. Hwang, Joseph J. H. Ackerman

   Pages 59-94

5. Metabolic and Physiological Responses of Mammary Carcinoma in the Mouse and Normal Brain Tissue in the Rat to Photodynamic Therapy

   • M. Chopp, Q. Jiang, Q. Chen, M. Dereski, F. W. Hetzel

   Pages 95-120

6. 31P and 2H MRS Studies of Flavone Acetic Acid and Analogues

   • Jeffrey L. Evelhoch, Nicholas E. Simpson, Frederick A. Valeriote, Thomas H. Corbett

   Pages 121-147

7. 13C and 31P NMR Studies of Prostate Tumor Metabolism

   • Laurel O. Sillerud, Karen R. Halliday, James P. Freyer, Richard H. Griffey, Cecilia Fenoglio-Preiser

   Pages 149-179

8. Use of 1H MRS of Plasma and Tissue in Cancer Detection and Management

   • John K. Saunders, Ian C. P. Smith

   Pages 181-198

9. Quantification of ³¹P NMR in vivo Spectra

   • T. R. Brown, S. J. Nelson, J. S. Taylor, D. B. Vigneron, J. Murphy-Boesch

   Pages 199-207

10. 31P NMR Studies of Superficial Murine and Human Tumors

    • J. A. Koutcher, D. Ballon, M. C. Graham, J. Healey, R. Heelan, L. Gerweck

    Pages 209-230

11. In Situ 31P-MRS as a Potential Predictor for Therapeutic Response of Human Neoplasms

    • Thian C. Ng, S. Vijayakumar, A. Majors, Melvin Tefft

    Pages 231-253

12. Integrated Magnetic Resonance Imaging and 31P-Magnetic Resonance Spectroscopy of Soft Tissue Masses

    • Michael A. Shinkwin, Robert E. Lenkinski, Michael B. Zlatkin, Herbert Y. Kressel, John M. Daly

    Pages 255-269

13. Preliminary 31P MR Studies of Human Tumors

    • G. S. Karczmar, D. J. Meyerhoff, B. Hubesch, M. D. Boska, F. Valone, D. B. Twieg et al.

    Pages 271-291

14. Combined MRI and 31P MRS for Diagnosis of Bone and Soft Tissue Lesions

    • W. G. Negendank, M. G. Crowley, J. R. Ryan, N. A. Keller, J. L. Evelhoch

    Pages 293-307

15. A Comparison of the Potential Roles of PET and MRS in Experimental and Clinical Oncology

    • Thomas F. Budinger

    Pages 309-325

16. MRI in the Diagnosis of Malignant Brain Tumors

    • H. Wilner

    Pages 327-338

17. Magnetic Resonance Imaging in the Patient with Cancer

    • Allan M. Haggar

    Pages 339-352

18. MRI of Hematologic Diseases: Marrow Imaging

    • L. L. Sensenbrenner, C. Karanes, L. Tranchida, V. Ratanatharathorn, A. M. Al-Katib, M. R. Smith et al.

    Pages 353-369

19. MRI of Breast Tumors: The Role of Image Processing

    • John K. Gohagan, Alice E. Tome, William A. Murphy, Edward L. Spitznagel, William G. Negendank, Nancy O. Whitley

    Pages 370-382

20. Back Matter

    Pages 383-391

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Over the past decade, techniques have been developed and implemented to observe metabolism noninvasively in localized regions of intact, living experimental animals and humans through the use of magnetic resonance spectroscopy (MRS). At the same time, magnetic resonance imaging (MRI) techniques developed in the 1970s and refined in this decade have been increasingly applied as a powerful clinical tool to probe human anatomy. Because of the unusual metabolic and physiologic characteristics of malignant tissues, oncology has been one of the primary focuses of the application of both MRS and MRI. Although considerable progress has been made in oncologic applications of magnetic resonance (MR), further research is needed to realize the full potential of MR in this area. Consequently, the 21st Annual Detroit Cancer Symposium entitled "Magnetic Resonance in Experimental and Clin­ ical Oncology" was organized to provide a forum for researchers in the field to report the state of the art of MRS and MRI in oncol­ ogy, to discuss future goals for MRS and MRI in oncology, and to define the research needed to meet those goals. The major emphasis of the symposium was on MRS due to both the recent widespread availability of clinical MRS instrumentation and the extensive amount of animal MRS research performed over the past half decade.

• Tumor
• carcinoma
• diagnosis
• imaging
• magnetic resonance imaging (MRI)
• magnetic resonance spectroscopy

• Wayne State University School of Medicine, Detroit, USA

  Jeffrey L. Evelhoch, William Negendank, Frederick A. Valeriote, Laurence H. Baker

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