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Natural Toxins 2

Structure, Mechanism of Action, and Detection

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 391)

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Table of contents (43 chapters)

  1. Front Matter

    Pages i-xi
  2. Overview of Toxins

    1. Marine Natural Products

      • Paul J. Scheuer
      Pages 1-8
    2. Plant Toxins

      • Gary D. Manners
      Pages 9-35
    3. Overview of Snake Venom Chemistry

      • Anthony T. Tu
      Pages 37-62
  3. Origin, Stucture and Function

    1. Structure and Function of Cobra Venom Factor, the Complement-Activating Protein in Cobra Venom

      • Carl-Wilhelm Vogel, Reinhard Bredehorst, David C. Fritzinger, Thomas Grunwald, Patrick Ziegelmüller, Michael A. Kock
      Pages 97-114
    2. The Staphylococcal and Streptococcal Pyrogenic Toxin Family

      • Gregory A. Bohach, Cynthia V. Stauffacher, Douglas H. Ohlendorf, Young-In Chi, Gregory M. Vath, Patrick M. Schlievert
      Pages 131-154
    3. PRIMARY STRUCTURAL MOTIFS OFConus PEPTIDES

      • Lourdes J. Cruz
      Pages 155-167
    4. Hymenoptera Venom Proteins

      • Donald R. Hoffman
      Pages 169-186
    5. Isolation of a Novel Lectin from the Globiferous Pedicellariae of the Sea Urchin Toxopneustes Pileolus

      • H. Nakagawa, H. Hashimoto, H. Hayashi, M. Shinohara, K. Ohura, E. Tachikawa et al.
      Pages 213-223
    6. Indian Catfish (Plotosus canius, Hamilton) Venom

      • B. Auddy, A. Gomes
      Pages 225-229
    7. Effects of Toxic Shock Syndrome Toxin-1 and a Site-Directed Mutant, H135A, in Mice

      • B. G. Stiles, T. Krakauer, P. F. Bonventre
      Pages 245-250
    8. The Relationship between Histidine Redidues and Various Biological Activities of Clostridium perfringens Alpha Toxin

      • Masahiro Nagahama, Sadayuki Ochi, Keiko Kobayashi, Jun Sakurai
      Pages 251-255

About this book

From beach encounters, aquaculture perils, and processed-food poisoning to snake bites and biological warfare, natural toxins seem never to be far from the public's sight. A better understanding of toxins in terms of their origin, structure, structure-function relation­ ships, mechanism of action, and detection and diagnosis is of utmost importance to human and animal food safety, nutrition, and health. In addition, it is now clear that many of the toxins can be used as scientific tools to explore the molecular mechanism of several biological processes, be it a mechanism involved in the function of membrane channels, exocytosis, or cytotoxicity. Several of the natural toxins have also been approved as therapeutic drugs, which has made them of interest to several pharmaceutical companies. For example, botulinum neurotoxins, which have been used in studies in the field of neurobiology, have also been used directly as therapeutic drugs against several neuromus­ cular diseases, such as strabismus and blepherospasm. Toxins in combination with modem biotechnological approaches are also being investigated for their potential use against certain deadly medical problems. For example, a combination of plant toxin ricin and antibodies is being developed for the treatment of tumors. The great potential of natural toxins has attracted scientists of varying backgrounds-pure chemists to cancer biologists-to the study of fundamental aspects of the actions of these toxins.

Keywords

  • bacteria
  • biology
  • enzymes
  • natural product
  • safety
  • toxicity
  • ecotoxicology

Editors and Affiliations

  • University of Massachusetts, Dartmouth, North Dartmouth, USA

    Bal Ram Singh

  • Colorado State University, Fort Collins, USA

    Anthony T. Tu

Bibliographic Information

Buying options

eBook
USD 139.00
Price excludes VAT (USA)
  • ISBN: 978-1-4613-0361-9
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 179.99
Price excludes VAT (USA)