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Cancer Markers

Diagnostic and Developmental Significance

  • Stewart Sell

Part of the Contemporary Biomedicine book series (CB, volume 1)

Table of contents

  1. Front Matter
    Pages i-xxvii
  2. G. Barry Pierce
    Pages 1-36
  3. Peter R. Panfili
    Pages 37-55
  4. Brigid G. Leventhal, Curt I. Civin, Gregory Reaman
    Pages 89-113
  5. Stanley E. Chism
    Pages 115-132
  6. George Griffing, Judith L. Vaitukaitis
    Pages 169-190
  7. Doris Balinsky
    Pages 191-224
  8. Charles H. W. Horne, Roy D. Bremner
    Pages 225-247
  9. Stewart Sell
    Pages 249-293
  10. John E. Shively, Charles W. Todd
    Pages 295-314
  11. David V. Gold, David M. Goldenberg
    Pages 329-369
  12. Ganesa Yogeeswaran
    Pages 371-401
  13. Lubomir S. Hnilica, Robert C. Briggs
    Pages 463-483
  14. Erkki Ruoslahti, Edward G. Hayman, Eva Engvall
    Pages 485-505
  15. R. W. Baldwin, R. A. Robins
    Pages 507-531
  16. Back Matter
    Pages 534-541

About this book

Introduction

Developmental cancer products (oncodevelopmental markers, ODM) not only serve as diagnostic and prognostic indicators but also may be used to study the nature of the carcinogenic process and the biology of tumors. For many years oncologists have searched for markers of cancer cells that would permit unequivocal recognition of cancer in contrast to noncancerous tissue. The earliest and still most widely used method of identification of cancer tissue or cells is the structural resemblance of cancer tissue to fetal or immature tissue. Pathologists not only recognize cancer by its morphologic similarity to fetal tissues, but also in many instances can relate the behavior of a given tumor to the degree of tissue differentiation. Thus, poorly differentiated tumors that resemble fetal tissue generally grow more rapidly and metastasize earlier than do well-differentiated tumors that more closely resemble adult tissue. In recent years the commonality of fetal and cancer tissue has been extended to products of tumor cells that, can be analyzed by biochemical, immunological, or physiological techniques. Increas­ ingly, products of cancer cells similar to fetal products are being identified and studied. These products range from cell-surface markers (fetal or differentiation antigens), placental proteins, hormones, and isoenzymes to a multitude of products, such as carcinoembryonic antigen (CEA), alphafetoprotein (AFP), lymphocyte markers, and nucleic acids, such as tRNA, that are produced in small amounts by v vi PREFACE continually differentiating cells in the adult but in much greater amounts by tumors.

Keywords

cancer carcinogenesis carcinoma cell classification embryo genetics hormones leukemia lymphoma melanoma pathogenesis thymus tissue tumor

Editors and affiliations

  • Stewart Sell
    • 1
  1. 1.Department of PathologyUniversity of California Medical SchoolSan Diego, La JollaUSA

Bibliographic information