Short-Term Tests for Chemical Carcinogens

  • H. F. Stich
  • R. H. C. San

Part of the Topics in Environmental Physiology and Medicine book series (TEPHY)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Viral Systems

    1. Andrew J. Rainbow
      Pages 20-35
  3. DNA

  4. Microbial Systems

  5. Higher Plants

    1. William F. Grant, A. E. Zinov’eva-Stahevitch, K. D. Zura
      Pages 200-216
  6. Chromosomes

    1. T. C. Hsu, William W. Au, Louise C. Strong, Dennis A. Johnston
      Pages 217-235

About these proceedings

Introduction

The recent surge of interest in designing, validating, and implementing short-term tests for carcinogens has been spurred by the fairly convincing correlation be­ tween the carcinogenicity and mutagenicity of chemicals and physical agents and by the assumption that DNA alteration, mutations, and chromosome aberrations are somehow involved in neoplastic transformation. Moreover, it has been tacitly assumed that the mutagenic capacity alone of compounds would induce regulatory agencies to pass rules for their removal from the environment and would lead the public to avoid them. The actual response, however, is quite different. Governmental departments shy away from making any decisions on the basis of in vitro test systems. The public at large is becoming irritated by daily an­ nouncements that many of their cherished habits could adversely affect their health. Industry appears to feel threatened and may reduce its search for new beneficial chemicals. The reluctance to accept wholeheartedly the mutagenicity tests for the detection of carcinogens is partly due to uncertainty about the in­ volvement of mutations in neoplastic transformation, partly due to the present difficulty of extrapolating results from various endpoints obtained on numerous organisms to man, and partly due to a multitude of complex events that lead in vivo to the evolvement of benign or malignant tumors.

Keywords

Calcium DNA Krebserregender Stoff Mutagene Mutation Nucleotide

Editors and affiliations

  • H. F. Stich
    • 1
  • R. H. C. San
    • 2
  1. 1.Environmental Carcinogenesis UnitBritish Columbia Cancer Research CentreVancouverCanada
  2. 2.Carcinogen Testing LaboratoryBritish Columbia Cancer Research CentreVancouverCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4612-5847-6
  • Copyright Information Springer-Verlag New York 1981
  • Publisher Name Springer, New York, NY
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-5849-0
  • Online ISBN 978-1-4612-5847-6
  • Series Print ISSN 0172-6048
  • About this book