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Human Cancer Markers

  • Stewart Sell
  • Britta Wahren

Part of the Contemporary Biomedicine book series (CB, volume 2)

Table of contents

  1. Front Matter
    Pages i-xx
  2. William C. Raschke
    Pages 1-32
  3. Robert Fox, Stephen Baird, Patrick Kung, Ron Levy, Ivor Royston
    Pages 33-68
  4. Jean-Claude Bystryn
    Pages 89-104
  5. Hans O. Sjögren, Britta Wahren
    Pages 105-132
  6. Stewart Sell
    Pages 133-164
  7. John R. Hobbs
    Pages 165-177
  8. T. Ming Chu, Ming C. Wang, Ching-li Lee, Carl S. Killian, Manabu Kuriyama, Lawrence D. Papsidero et al.
    Pages 179-190
  9. Thomas S. Edgington, Robert M. Nakamura
    Pages 191-232
  10. Markku Seppälä
    Pages 233-257
  11. Paul H. Lange
    Pages 259-273
  12. Torgny Stigbrand, Eva Engvall
    Pages 275-301
  13. Britta Wahren, Peter Perlmann
    Pages 303-319
  14. Geoffrey Mendelsohn, Stephen B. Baylin
    Pages 321-358
  15. K. Robert McIntire
    Pages 359-380
  16. Trevor R. Jones, Darell D. Bigner
    Pages 381-422
  17. Back Matter
    Pages 423-428

About this book

Introduction

The ability to diagnose cancer by simple measurement of a serum or tissue' 'marker" has been a goal of medical science for many years. There is ample evidence that tumor cells are different from normal cells and pro­ duce substances that can be detected by currently available immuno­ chemical or biochemical methods. These "cancer markers" may be se­ creted proteins, enzymes, hormones, fetal serum components, monoclonal immunoglobulins, cell surface components, or cytoplasmic constituents. The purpose of this book is to present the current status of our knowledge of such cancer markers. The first tumor marker identified by laboratory means was Bence­ Jones protein. In a series of lectures delivered to the Royal College of Phy­ sicians in London in 1846, Dr. H. Bence Jones described studies on a urine sample sent to him with the following note: "Dear Dr. Jones-The tube contains urine of very high specific gravity. When boiled it becomes slightly opaque . . . . etc. " Dr. Jones found that heating of the urine after addition of nitric acid resulted in formation of a heavy precipitate; acid ad­ dition may have been required to bring the urine to pH 4-6 at which Bence Jones proteins are more likely to precipitate when heated. This urinary pre­ cipitate was associated with a bone disease termed "mollities ossium. " [H. Bence Jones, Papers on Chemical Pathology, Lecture III. Lancet 2, 269-274 (1847)].

Keywords

CT Staging cancer carcinoma cell computed tomography (CT) gastric cancer hormones leukemia lymphocytes lymphoma melanoma pathology tissue tumor

Editors and affiliations

  • Stewart Sell
    • 1
  • Britta Wahren
    • 2
  1. 1.University of CaliforniaSan DiegoUSA
  2. 2.Karolinska HospitalStockholmSweden

Bibliographic information