Assay of Calcium-regulating Hormones

  • Daniel D. Bikle

Table of contents

  1. Front Matter
    Pages i-xii
  2. Claude D. Arnaud
    Pages 1-19
  3. Sara B. Arnaud, Juliann Meger
    Pages 65-83
  4. Phillip W. Lambert, Irene Y. Fu, David M. Kaetzel, Bruce W. Hollis
    Pages 99-124
  5. Bernard P. Halloran
    Pages 125-137
  6. Stavros C. Manolagas
    Pages 139-150
  7. Anne P. Teitelbaum
    Pages 191-206
  8. Charles D. Hawker
    Pages 207-227
  9. Hunter Heath III, Glen W. Sizemore
    Pages 229-245
  10. Robert A. Nissenson
    Pages 247-259
  11. Back Matter
    Pages 269-271

About this book

Introduction

The ability to measure accurately the hormones regulating calcium homeosta­ sis is the fundamental first step toward understanding the roles these hormones play in health and disease. Techniques for such measurements have only been available for the past 10 years or so and remain in a state of rapid development. Sensitive parathyroid hormone (PTH) radioimmunoassays appeared in the early 1970s, and with them came a whole new appreciation for the prevalence and implications of hyperparathyroidism, primary or secondary, in the popu­ lation. The calcitonin (CT) radioimmunoassay came later and achieved rapid success in the. diagnosis of a previously poorly understood cancer, medullary carcinoma of the thyroid, frequently associated with the familial multiple endo­ crine neoplasia type 2 syndromes (a and b). As the sensitivity of the calcitonin radioimmunoassay has improved, our understanding of the role of calcitonin in normal physiological processes has increased. The knowledge that vitamin D must be metabolized to produce its biologic effects is only 15 years old. This has had profound implications in our understanding of a variety of metabolic bone, kidney, and gastrointestinal diseases. Assays to measure the major cir­ culating form of vitamin D, 25-hydroxyvitamin D, were described 10 years ago. Assays for the other metabolites, in particular, 1,25-dihydroxyvitamin D, were described even more recently. As of today, we know of many vitamin D metabolites and have developed the techniques to measure most of them; how­ ever, many questions remain concerning their physiological role.

Keywords

Assay Calcium Calzitonin Hormones Immunologie Parathormon Radioimmunologie Vitamin D bone homeostasis hormone receptor thyroid hormone

Editors and affiliations

  • Daniel D. Bikle
    • 1
  1. 1.Department of MedicineUniversity of California, San Francisco Veterans Administration Medical CenterSan FranciscoUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4612-5553-6
  • Copyright Information Springer-Verlag New York 1983
  • Publisher Name Springer, New York, NY
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-5555-0
  • Online ISBN 978-1-4612-5553-6
  • About this book