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Vitamins and Cancer

Human Cancer Prevention by Vitamins and Micronutrients

  • Frank L. MeyskensJr.
  • Kedar N. Prasad

Part of the Experimental Biology and Medicine, Vol. 10 book series (EBAM, volume 10)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Basic Experimental Approaches

  3. Chemoprevention (Preclinical)

    1. Front Matter
      Pages 111-111
    2. Paul M. Newberne, Thomas F. Schrager, Michael W. Conner
      Pages 113-138
    3. L. Santamaria, A. Bianchi, A. Arnaboldi, L. Andreoni, G. Santagati, C. Ravetto et al.
      Pages 139-159
    4. R. C. Moon, D. L. McCormick, R. G. Mehta
      Pages 161-180
    5. Selwyn A. Broitman, Herbert Z. Kupchik, Leonard S. Gottlieb
      Pages 181-197
    6. Mary P. Carpenter
      Pages 199-211
  4. Chemoprevention (Human)

    1. Front Matter
      Pages 229-229
    2. Methodological Issues

      1. David S. Alberts, Libby Edwards, Yei-Mei Peng, Ruth Serokman, Thomas P. Davis, Frank L. Meyskens Jr.
        Pages 245-255
      2. Thomas E. Moon, Steven Ross Rodney, Yei-Mei Peng, David S. Alberts, Frank Meyskens
        Pages 267-281
      3. Charles H. Hennekens, Sherry Mayrent
        Pages 283-289
    3. Prevention Trials

      1. William D. Dewys, Winfred F. Malone, Mary Ann Sestili, Gary J. Kelloff, Charles W. Boone
        Pages 301-310
      2. L. S. Freedman, S. Groshen, H. H. Miller, J. J. DeCosse
        Pages 329-340
      3. G. E. Goodman, G. S. Omenn, P. Feigl, G. D. Kleinman, B. Lund, D. D. Thomas et al.
        Pages 341-350
  5. Treatment

    1. Front Matter
      Pages 363-363
    2. Alfred Hanck
      Pages 365-397
    3. Fukumi Morishige, Takahide Nakamura, Naoko Nakamura, Noritsugu Morishige
      Pages 399-427
    4. H.-A Ladner, R. M. Salkeld, H.-A Ladner
      Pages 429-437
    5. Emmanuel C. Besa, Martin Hyzinski, Peter Nowell, Janet Abrahm
      Pages 453-469
  6. Back Matter
    Pages 479-481

About this book

Introduction

In the past five years, a surprising and intense resurgence in interest in vitamins and other micronutrients and their role in health and dis­ ease has occurred. The recognition has emerged that vitamins not only are essential for life ·in that severe nutritional deficiencies occur in their absence, but that these compounds may also serve as natural inhibitors of cancer. Synthetic alterations of the basic vitamin A mole­ cule have also resulted in the production of compounds that are more potent as anticancer agents than the natural substance and may have substantial therapeutic activity as well. Whether other vita­ mins can be changed or altered to produce a better anticancer effect than the native compound has been little explored to date, but should be a fruitful pursuit for future study. In our concluding remarks to the First International Conference in 1982, we speculated that rapid advances in our understanding of vi­ tamins would occur in the next few years and that large-scale inter­ vention trials of vitamins as preventive agents in defined human pop­ ulations would be started. This anticipated generation of data on vitamins and their interactions has proceeded rapidly and the impor­ tance of interactions between vitamins and other micronutrients in the prevention setting has become better appreciated. Currently, more than 25 intervention trials with a variety of target populations using vitamins and other micronutrients have been started, but it re­ mains too early for meaningful analysis of the results to date.

Keywords

cancer prevention carcinoma cell clinical trial gastric cancer melanoma prevention tumor tumorigenesis

Editors and affiliations

  • Frank L. MeyskensJr.
    • 1
  • Kedar N. Prasad
    • 2
  1. 1.Section of Hematology/OncologyCancer Center, Arizona Health Sciences CenterTucsonUSA
  2. 2.Center of Vitamins and Cancer Research Department of RadiologyUniversity of Colorado Health Sciences CenterDenverUSA

Bibliographic information