Manual of Pharmacologic Calculations

1. Enzyme Kinetics II: Competitive Inhibition

   • Ronald J. Tallarida, Rodney B. Murray

   Pages 63-66

2. Enzyme Kinetics III: Noncompetitive Inhibition

   • Ronald J. Tallarida, Rodney B. Murray

   Pages 66-69

3. First-Order Drug Decay

   • Ronald J. Tallarida, Rodney B. Murray

   Pages 69-71

4. Scatchard Plot

   • Ronald J. Tallarida, Rodney B. Murray

   Pages 72-74

5. Henderson—Hasselbalch Equation

   • Ronald J. Tallarida, Rodney B. Murray

   Pages 74-75

6. Exponential Growth and Decay

   • Ronald J. Tallarida, Rodney B. Murray

   Pages 75-77

7. Area under a Curve: Trapezoidal and Simpson’s Rules

   • Ronald J. Tallarida, Rodney B. Murray

   Pages 77-81

8. Pharmacokinetics I: Constant Infusion with First-Order Elimination

   • Ronald J. Tallarida, Rodney B. Murray

   Pages 82-86

9. Pharmacokinetics II: Multiple Intravenous Injections

   • Ronald J. Tallarida, Rodney B. Murray

   Pages 86-89

10. Pharmacokinetics III: Volume of Distribution

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 89-93

11. Pharmacokinetics IV: Absorptive Route of Administration Plasma Concentration-Time Data

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 93-98

12. Pharmacokinetics V: Renal Clearance

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 98-102

13. Pharmacokinetics VI: Renal Excretion Data Following Intravenous Administration

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 103-104

14. Pharmacokinetics VII: Multiple Dosing from Absorptive Site

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 105-109

15. Analysis of Variance I: One-Way

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 110-112

16. Analysis of Variance II: Two-Way, Single Observation

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 113-116

17. Analysis of Variance III: Two-Way, with Replication

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 117-120

18. Newman-Keuls Test

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 121-124

19. Duncan Multiple Range Test

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 125-127

20. Least Significant Difference Test

    • Ronald J. Tallarida, Rodney B. Murray

    Pages 128-130

This book contains a collection of quantitative procedures in common use in pharmacology and related disciplines. It is intended for students and researchers in all fields who work with drugs. Many physicians, especially those concerned with clinical pharmacology, will also find much that is useful. The procedures included may be considered "core" since they are generally applicable to all classes of drugs. Some of the procedures deal with statistics and, hence, have even wider application. In this new edition we have increased the number of procedures from 33 (in the first edition) to 48. Other procedures have been revised and expanded. Yet the basic philosophy of this new edition remains unchanged from the first. That is, the pharmacologic basis of each procedure is presented, along with the necessary formulas and one or more worked examples. An associated computer program is included for each procedure and its use is illustrated with the same worked example used in the text. The discussions of theory and the sample computations are brief and self-contained, so that all computations can be made with the aid of a pocket calculator and the statistical tables contained in Appendix A. Yet it is realized that the proliferation of lower-priced microcom­ puters is likely to mean that more and more readers will utilize a computer for most calculations. Accordingly, we have modified the format of the book to facilitate computer usage.

• Calculation
• Pharmakologie
• pharmacology
• research
• statistics

• Department of Pharmacology, Temple University School of Medicine, Philadelphia, USA

  Ronald J. Tallarida

• Department of Pharmacology, Biosearch Inc., Philadelphia, USA

  Rodney B. Murray

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