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Gene Regulation by Steroid Hormones IV

  • Arun K. Roy
  • James H. Clark
Conference proceedings

Table of contents

  1. Front Matter
    Pages i-xi
  2. Yan Min Wang, Kerry Burnstein, Corinne Silva, Deborah Bellingham, Douglas Tully, Jorge Simental et al.
    Pages 23-40
  3. Donald J. Gruol, Maureen T. Harrigan, Suzanne Bourgeois
    Pages 41-61
  4. W. Schmid, U. Strahle, R. Mestril, G. Klock, W. Ankenbauer, G. Schutz
    Pages 78-89
  5. José-Luis Castrillo, Lars E. Theill, Mordechai Bodner, Michael Karin
    Pages 90-109
  6. D. S. Loose-Mitchell, C. Chiappetta, R. M. Gardner, J. L. Kirkland, T.-H. Lin, R. B. Lingham et al.
    Pages 110-132
  7. Young-Ping Hwung, David T. Crowe, Lee-Ho Wang, Sophia Y. Tsai, Ming-Jer Tsai
    Pages 133-143
  8. J. R. Tata, H. Lerivray, J. Marsh, S. C. Martin
    Pages 163-181
  9. B. Chatterjee, W. F. Demyan, W. Gallwitz, J. M. Kim, M. A. Mancini, D. H. Oh et al.
    Pages 199-212
  10. Barry M. Markaverich, Brian S. Middleditch, James Clark
    Pages 213-219
  11. Orla M. Conneely, Denise Kettelberger, Ming-Jer Tsai, Bert W. O’Malley
    Pages 220-233
  12. Back Matter
    Pages 235-239

About these proceedings

Introduction

The first Meadowbrook Symposium was held in 1978 and during the intervening ten years our knowledge concerning how steroid hormones function at the level of gene expression has advanced by leaps and bounds. In this volume, which sum­ marizes our fourth meeting, these advances are very evident. What seemed like science fiction ten years ago has become commonplace science. Who would have imagined that we could synthesize a nucleotide sequence that binds a specific steroid receptor and acts as a controlling element for gene expression? No one; but as is evident from the results reported in several chapters, this technique is yielding a wealth of information. Using these and other techniques it has become apparent that gene transcription is controlled by interactions between transacting factors and DNA recognition sequences (response elements). These transacting factors appear to be members of a large gene family that includes steroid hormone receptors, transcription factors, protooncogenes and homeobox proteins. Thus a great deal has been learned, but as usual, questions remain. Many of these questions are posed by the findings and observations found in several chapters in this volume. Non­ hormone binding forms of steroid receptors and their relevance to receptor down regulation, recycling and biological response remain a mystery. The quantitative relationship between receptor binding and biological response still presents agonizing problems. These and many other intriguing questions are discussed in this volume and set the stage for what should be a most rewarding time in endocrinology. Winter 1989 ARUN K.

Keywords

DNA EGF receptor Insulin Nucleotide Regulation gene expression hormone receptors proteins tissue transcription

Editors and affiliations

  • Arun K. Roy
    • 1
  • James H. Clark
    • 2
  1. 1.Division of Molecular Genetics, Department of Obstetrics and GynecologyUniversity of Texas Health Science CenterSan AntonioUSA
  2. 2.Department of Cell BiologyBaylor College of MedicineHoustonUSA

Bibliographic information