Autoimmunity and the Pathogenesis of Diabetes

  • Fredda Ginsberg-Fellner
  • Robert C. McEvoy

Part of the Endocrinology and Metabolism book series (EAM, volume 4)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Heike Bärmeier, Michael Christie, Betsy Herold, Kevan Herold, Åke Lernmark
    Pages 87-104
  3. Jerry P. Palmer
    Pages 147-164
  4. Yi Wang, Liming Hao, Kevin J. Lafferty
    Pages 184-205
  5. Back Matter
    Pages 283-296

About this book

Introduction

It has been a challenge for us to edit this volume of Endocrinology and Metabo­ lism: Progress in Research and Clinical Practice. The topic of the pathogenesis of insulin-dependent, type I diabetes mellitus is particularly appropriate for this series, since advances in this area have been made, to a large extent, by applying state-of-the-art laboratory techniques to clinical samples. Over the last several years, a number of lines of evidence have been gathered, suggesting that classic type I diabetes mellitus results from the autoimmune des­ truction of pancreatic beta-cells in genetically susceptible individuals. This hypothesis is particularly appealing because it offers a rational approach to the prevention of diabetes by immunosuppression. We have tried to present a balanced, authoritative summary of the information currently available to support the autoimmune hypothesis for the pathogenesis of human type I diabetes, to place this information in historical perspective, to include relevant information from animal models of type I diabetes in which more invasive experimentation is ethical, and, finally, to update the reader on the current status of attempts to intervene in the progression of diabetes with immunosuppressive drugs. New York, New York Fredda Ginsberg-Fellner Robert C. McEvoy Contents Preface.. . . .. .. .. . . . . . . . . . . . . ... . . . . . . . . . . . .. . . . . . . .. . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Xl . . . . . . . . . . . . . 1. The Autoimmune Hypothesis of Insulin-Dependent Diabetes: 1965 to the Present . . . . . . . . . . . . ..................... . . . . . .

Keywords

Antigen Diabetes Diabetes mellitus Insulin Pancreas Pancreatic Islets Termination autoimmune disease autoimmunity genetics immunosuppression immunotherapy infection pathogenesis virus

Editors and affiliations

  • Fredda Ginsberg-Fellner
    • 1
  • Robert C. McEvoy
    • 2
  1. 1.Division of Pediatric Endocrinology and MetabolismMount Sinai School of MedicineNew YorkUSA
  2. 2.Mount Sinai School of MedicineNew YorkUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4612-3218-6
  • Copyright Information Springer-Verlag New York 1990
  • Publisher Name Springer, New York, NY
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-7920-4
  • Online ISBN 978-1-4612-3218-6
  • Series Print ISSN 0938-040X
  • About this book